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大肠杆菌中的核糖核酸合成与谷氨酸排泄

Ribonucleic acid synthesis and glutamate excretion in Escherichia coli.

作者信息

Broda P

出版信息

J Bacteriol. 1968 Nov;96(5):1528-34. doi: 10.1128/jb.96.5.1528-1534.1968.

DOI:10.1128/jb.96.5.1528-1534.1968
PMID:4973126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC315205/
Abstract

Cultures of Escherichia coli excreted glutamate into the medium when protein synthesis was blocked in RC(rel) strains or when it was blocked with chloramphenicol in either RC(str) or RC(rel) strains. Both of these conditions resulted in continued ribonucleic acid (RNA) synthesis in the absence of protein synthesis. Glutamate was also excreted by both RC(str) and RC(rel) strains when RNA synthesis was inhibited by uracil starvation or by treatment with actinomycin D. It is proposed that, in each of these cases, glutamate excretion resulted from an increase in the permeability of the cell membrane.

摘要

当蛋白质合成在RC(rel)菌株中受阻时，或者当蛋白质合成在RC(str)或RC(rel)菌株中被氯霉素阻断时，大肠杆菌培养物会将谷氨酸分泌到培养基中。这两种情况都会导致在没有蛋白质合成的情况下核糖核酸（RNA）继续合成。当尿嘧啶饥饿或用放线菌素D处理抑制RNA合成时，RC(str)和RC(rel)菌株也会分泌谷氨酸。有人提出，在上述每种情况下，谷氨酸的分泌都是由于细胞膜通透性增加所致。

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1
Ribonucleic acid synthesis and glutamate excretion in Escherichia coli.大肠杆菌中的核糖核酸合成与谷氨酸排泄
J Bacteriol. 1968 Nov;96(5):1528-34. doi: 10.1128/jb.96.5.1528-1534.1968.
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本文引用的文献

1
Gene Recombination and Linked Segregations in Escherichia Coli.大肠杆菌中的基因重组与连锁分离
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2
Growth Requirements of Virus-Resistant Mutants of Escherichia Coli Strain "B".大肠杆菌菌株“B”的抗病毒突变体的生长需求
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Some physiological and genetic properties of a strain of Escherichia coli requiring thymine, arginine and uracil.一株需要胸腺嘧啶、精氨酸和尿嘧啶的大肠杆菌的某些生理和遗传特性。
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A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTA.乙二胺四乙酸（EDTA）导致大肠杆菌通透性非特异性增加。
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EFFECT OF BIOTIN ON FATTY ACID DISTRIBUTION IN ESCHERICHIA COLI.生物素对大肠杆菌脂肪酸分布的影响
J Bacteriol. 1965 Feb;89(2):437-43. doi: 10.1128/jb.89.2.437-443.1965.
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BIOTIN DEFICIENCY AND THE FATTY ACIDS OF CERTAIN BIOTIN-REQUIRING BACTERIA.生物素缺乏与某些需要生物素的细菌的脂肪酸
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Actinomycin D: inhibition of phospholipid synthesis in chick embryo cells.放线菌素D：对鸡胚细胞中磷脂合成的抑制作用。
Science. 1968 Apr 19;160(3825):316-7. doi: 10.1126/science.160.3825.316.
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Mechanism of action of phenethyl alcohol: breakdown of the cellular permeability barrier.苯乙醇的作用机制：细胞通透性屏障的破坏。
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