大肠杆菌中的核糖核酸合成与谷氨酸排泄
Ribonucleic acid synthesis and glutamate excretion in Escherichia coli.
作者信息
Broda P
出版信息
J Bacteriol. 1968 Nov;96(5):1528-34. doi: 10.1128/jb.96.5.1528-1534.1968.
Abstract
Cultures of Escherichia coli excreted glutamate into the medium when protein synthesis was blocked in RC(rel) strains or when it was blocked with chloramphenicol in either RC(str) or RC(rel) strains. Both of these conditions resulted in continued ribonucleic acid (RNA) synthesis in the absence of protein synthesis. Glutamate was also excreted by both RC(str) and RC(rel) strains when RNA synthesis was inhibited by uracil starvation or by treatment with actinomycin D. It is proposed that, in each of these cases, glutamate excretion resulted from an increase in the permeability of the cell membrane.
摘要
当蛋白质合成在RC(rel)菌株中受阻时，或者当蛋白质合成在RC(str)或RC(rel)菌株中被氯霉素阻断时，大肠杆菌培养物会将谷氨酸分泌到培养基中。这两种情况都会导致在没有蛋白质合成的情况下核糖核酸（RNA）继续合成。当尿嘧啶饥饿或用放线菌素D处理抑制RNA合成时，RC(str)和RC(rel)菌株也会分泌谷氨酸。有人提出，在上述每种情况下，谷氨酸的分泌都是由于细胞膜通透性增加所致。
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