苯乙醇的作用机制：细胞通透性屏障的破坏。
Mechanism of action of phenethyl alcohol: breakdown of the cellular permeability barrier.
作者信息
Silver S, Wendt L
出版信息
J Bacteriol. 1967 Feb;93(2):560-6. doi: 10.1128/jb.93.2.560-566.1967.
Abstract
Phenethyl alcohol (PEA) caused Escherichia coli to take up greatly increased amounts of acriflavine, a compound to which healthy growing cells are impermeable. PEA also caused an increased rate of efflux (leakage) of cellular potassium under conditions which do not greatly alter the influx of potassium via the energy-dependent potassium pump. We therefore propose that the primary effect of PEA is a limited breakdown of the cell membrane. The inhibition of deoxyribonucleic acid synthesis and other cellular functions would then be secondary consequences of the alteration in the membrane structure.
摘要
苯乙醇（PEA）使大肠杆菌摄取的吖啶黄量大幅增加，而吖啶黄是一种健康生长的细胞无法通透的化合物。在不会显著改变通过能量依赖性钾泵的钾流入量的条件下，PEA还导致细胞内钾的流出（泄漏）速率增加。因此，我们提出PEA的主要作用是使细胞膜发生有限的破坏。脱氧核糖核酸合成及其他细胞功能的抑制随后将是膜结构改变的次要后果。
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本文引用的文献
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