Komendantova M V, Bender K I, Kupchikov V V, Poshuk L K
Farmakol Toksikol. 1979 Nov-Dec;42(6):611-4.
It has been established that morphine interacts with albumins, alpha 2- and beta-globulins, while promedol with all globulin fractions and to a less measure with plasma albumins of the intact rabbit. Interaction of morphine and especially that of promedol with the same protein fractions of allergizated animals proceeds more actively and is characterized by a more pronounced formation of biological complexes with alpha 1-globulins. Decreased pharmacological activity of morphine and promedol coincides with intensification of their interaction with proteins.
已经确定吗啡与白蛋白、α2球蛋白和β球蛋白相互作用，而异丙嗪与所有球蛋白组分相互作用，与完整兔子的血浆白蛋白相互作用程度较小。吗啡尤其是异丙嗪与致敏动物相同蛋白质组分的相互作用更活跃，其特征是与α1球蛋白形成更明显的生物复合物。吗啡和异丙嗪药理活性的降低与其与蛋白质相互作用的增强相吻合。
