Barber C, Eylan E
Zentralbl Bakteriol Orig A. 1975;230(4):452-7.
Immunizations of mice with proteins from S. paratyphi B protected the animals against infection with a concentration of S. paratyphi C which killed the controls and against an infection with 50 LD100 of the homologous S. paratyphi B. The sera of the infected mice showed common precipitation lines of proteins from the two species belonging to different serogroups. Consecutive inoculations with S. typhimurium of both groups of vaccinated mice protected the animals against the infection with their natural pathogen. Immunizations with proteins from S. cholerae-suis protected about 70% of the mice infected with S. paratyphi B and with S. paratyphi C; a higher protection was not, however, induced against infection with the homologous strain. Consecutive infections with S. typhi-murium of the mice resulted in total protection of the animals previously inoculated with S. paratyphi B and S. paratyphi C; the group of mice infected with S. cholerae-suis was less protected against the subsequent inoculation with S. typhi-murium (about 50%). In the infections of mice, S. paratyphi B and S. paratyphi C, seem related to S. typhi-murium by common proteins; the proportion of common protective determinants is not yet known.
用副伤寒乙杆菌的蛋白质对小鼠进行免疫接种，可使动物抵抗副伤寒丙杆菌的感染（副伤寒丙杆菌的浓度可致对照动物死亡），并抵抗50个同源副伤寒乙杆菌半数致死量的感染。受感染小鼠的血清显示，来自两个不同血清群的菌种的蛋白质有共同沉淀线。两组接种疫苗的小鼠连续接种鼠伤寒沙门氏菌，可使动物抵抗其自然病原体的感染。用猪霍乱沙门氏菌的蛋白质进行免疫接种，可使约70%感染副伤寒乙杆菌和副伤寒丙杆菌的小鼠得到保护；然而，对于同源菌株的感染，并未诱导出更高的保护率。小鼠连续感染鼠伤寒沙门氏菌，可使先前接种副伤寒乙杆菌和副伤寒丙杆菌的动物得到完全保护；感染猪霍乱沙门氏菌的小鼠组对随后接种鼠伤寒沙门氏菌的抵抗力较弱（约50%）。在小鼠感染中，副伤寒乙杆菌和副伤寒丙杆菌似乎通过共同蛋白质与鼠伤寒沙门氏菌相关；共同保护性决定簇的比例尚不清楚。
