Eylan E, Barber C
Zentralbl Bakteriol Orig A. 1978 Nov;242(1):12-6.
Mice immunized with proteins from S. typhimurium and from S. paratyphi C resisted the toxicity of a concentration of S. paratyphi A which killed the controls; this is in contrast to the results found in mice immunized with the same amount of proteins from the homologous S. paratyphi A. For the neutralization of the S. paratyphi A toxicity a higher quantity of homologous proteins was necessary in the immunizations. It is assumed that either S. paratyphi A synthesizes--on artificial media--a small amount of proteins responsible for the induction of neutralizing antibodies or that it is an intrinsic weak immunogen. In the sera of mice in which sufficient neutralizing antibodies were induced, the proteins of S. paratyphi A cross-reacted in agar-gel, with the proteins from S. typhimurium and from S. paratyphi C.
用鼠伤寒沙门氏菌和副伤寒丙沙门氏菌的蛋白质免疫的小鼠，能抵抗一定浓度的甲型副伤寒沙门氏菌的毒性，而相同浓度的该菌可杀死对照小鼠；这与用相同量的同源甲型副伤寒沙门氏菌蛋白质免疫的小鼠所得到的结果相反。为中和甲型副伤寒沙门氏菌的毒性，免疫时需要更多数量的同源蛋白质。据推测，要么甲型副伤寒沙门氏菌在人工培养基上合成少量负责诱导中和抗体的蛋白质，要么它本身就是一种弱免疫原。在诱导出足够中和抗体的小鼠血清中，甲型副伤寒沙门氏菌的蛋白质在琼脂凝胶中与鼠伤寒沙门氏菌和副伤寒丙沙门氏菌的蛋白质发生交叉反应。
