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低剂量辐射致癌作用

Radiation carcinogenesis at low doses.

作者信息

Rossi H H, Kellerer A M

出版信息

Science. 1972 Jan 14;175(4018):200-2. doi: 10.1126/science.175.4018.200.

DOI:10.1126/science.175.4018.200
PMID:5008441
Abstract

An analysis of experimental findings indicates that the induction of a manmmary neoplasm in the Sprague-Dawley rat is dependent on the action of radiation on more than one cell. Although a linear relation between incidence and x-ray dose might be consistent with available data, such a relation would be fortuitous and linear extrapolation to lower doses is unjustified.

摘要

对实验结果的分析表明,在斯普拉格-道利大鼠中诱发乳腺肿瘤依赖于辐射作用于多个细胞。尽管发病率与X射线剂量之间的线性关系可能与现有数据一致,但这种关系将是偶然的,并且向较低剂量进行线性外推是不合理的。

相似文献

1
Radiation carcinogenesis at low doses.低剂量辐射致癌作用
Science. 1972 Jan 14;175(4018):200-2. doi: 10.1126/science.175.4018.200.
2
Mammary neoplasia in the rat following high-energy neutron irradiation.高能中子辐照后大鼠的乳腺肿瘤形成
Cancer Res. 1977 Aug;37(8 Pt 1):2619-23.
3
Induction of mammary neoplasms in the Sprague-Dawley rat by 430keV neutrons and X-rays.430keV 中子和 X 射线诱导斯普拉格-道利大鼠乳腺肿瘤
J Natl Cancer Inst. 1980 Apr;64(4):821-33.
4
Reevaluation of the number of cells involved in the neutron induction of mammary neoplasms.对中子诱导乳腺肿瘤中所涉及细胞数量的重新评估。
Cancer Res. 1978 Jan;38(1):189-92.
5
High mammary carcinogenicity of neutron irradiation in rats and its promotion by prolactin.中子辐照对大鼠的高乳腺致癌性及其受催乳素的促进作用。
Jpn J Cancer Res. 1985 Jun;76(6):449-56.
6
Effects of radiation type and dose and the role of glucocorticoids, gonadectomy, and thyroidectomy in mammary tumor induction in mammotropin-secreting pituitary tumor-grafted rats.
Cancer Res. 1978 Jun;38(6):1507-13.
7
Role of prolactin in rat mammary carcinogenesis: detection of carcinogenicity of low-dose carcinogens and of persisting dormant cancer cells.
J Natl Cancer Inst. 1977 Jun;58(6):1777-83. doi: 10.1093/jnci/58.6.1777.
8
Relative biological effectiveness for neutron carcinogenesis in monkeys and rats.猴子和大鼠中子致癌的相对生物效应
Radiat Res. 1991 Oct;128(1 Suppl):S128-35.
9
Induction of mammary neoplasms in the ACI rat by 430-keV neutrons, X-rays, and diethylstilbestrol.430千电子伏特中子、X射线和己烯雌酚诱发ACI大鼠乳腺肿瘤
J Natl Cancer Inst. 1982 Nov;69(5):1135-46.
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Age Modifies the Effect of 2-MeV Fast Neutrons on Rat Mammary Carcinogenesis.年龄改变2兆电子伏快中子对大鼠乳腺癌发生的影响。
Radiat Res. 2017 Oct;188(4):419-425. doi: 10.1667/RR14829.1. Epub 2017 Aug 15.

引用本文的文献

1
Correlation between infectious disease and soil radiation in Japan: an exploratory study using national sentinel surveillance data.日本传染病与土壤辐射之间的相关性:一项使用全国哨点监测数据的探索性研究。
Epidemiol Infect. 2017 Apr;145(6):1183-1192. doi: 10.1017/S0950268816003034. Epub 2017 Jan 16.
2
Current knowledge on tumour induction by computed tomography should be carefully used.应当谨慎使用关于计算机断层扫描诱发肿瘤的现有知识。
Eur Radiol. 2014 Mar;24(3):649-56. doi: 10.1007/s00330-013-3047-z. Epub 2013 Nov 27.
3
Responses to low doses of ionizing radiation in biological systems.
生物系统对低剂量电离辐射的反应。
Nonlinearity Biol Toxicol Med. 2004 Jul;2(3):143-71. doi: 10.1080/15401420490507431.
4
Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach.估算极低剂量辐射诱发癌症的风险:采用线性无阈模型的基本原理
Radiat Environ Biophys. 2006 Mar;44(4):253-6. doi: 10.1007/s00411-006-0029-4. Epub 2006 Feb 10.
5
Recent reports on the effect of low doses of ionizing radiation and its dose-effect relationship.近期关于低剂量电离辐射的影响及其剂量效应关系的报告。
Radiat Environ Biophys. 2006 Mar;44(4):245-51. doi: 10.1007/s00411-006-0032-9. Epub 2006 Feb 9.
6
The estimation of low-dose hazards by extrapolation from high doses.通过高剂量外推来估计低剂量危害。
Yale J Biol Med. 1981 Sep-Oct;54(5):339-44.
7
Considerations on the time factor in radiobiology.放射生物学中时间因素的考量
Radiat Environ Biophys. 1981;20(1):1-9. doi: 10.1007/BF01323921.
8
Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation.急性暴露后人群辐射致癌的流行病学研究:核爆炸与医疗辐射
Yale J Biol Med. 1981 Nov-Dec;54(6):457-69.
9
Radiation risks of mammography.乳房X光检查的辐射风险。
West J Med. 1976 Dec;125(6):493-5.
10
Assumption of linearity in dose--effect relationships.剂量-效应关系中的线性假设。
Environ Health Perspect. 1978 Feb;22:103-5. doi: 10.1289/ehp.7822103.