Mukkur T K
J Gen Microbiol. 1979 Jul;113(1):37-43. doi: 10.1099/00221287-113-1-37.
Immunization of mice with a potassium thiocyanate extract of Pasteurella multocida type A (bovine strain) imparted complete protection against an experimental challenge infection with 1.6 x 10(3) colony-forming units of the homologous strain. Formalin-treated vaccine (one or two doses) was much less effective. Significantly higher bactericidal antibody titres were observed in the sera of mice immunized with the extract compared with those given the vaccine. The bactericidal activity was localized in the IgM and IgG fractions. The extract consisted of protein(s) and carbohydrate(s) and on immunoelectrophoresis displayed at least three antigenetically distinct components.
用A型多杀性巴氏杆菌（牛菌株）的硫氰酸钾提取物免疫小鼠，可使其对1.6×10³个同源菌株菌落形成单位的实验性攻击感染产生完全保护。经福尔马林处理的疫苗（一剂或两剂）效果要差得多。与接种疫苗的小鼠相比，用提取物免疫的小鼠血清中观察到显著更高的杀菌抗体滴度。杀菌活性定位于IgM和IgG组分中。该提取物由蛋白质和碳水化合物组成，在免疫电泳中显示至少三种抗原性不同的成分。
