Dickson J A, McKenzie A, McLeod K
J Appl Physiol Respir Environ Exerc Physiol. 1979 Oct;47(4):712-7. doi: 10.1152/jappl.1979.47.4.712.
Temperature was simultaneously measured by thermistors in multiple deep-body and peripheral sites in adult pigs heated continuously at 42 degrees C (rectal) and above for 4-24 h. During hyperthermia, the relations between different body temperatures were maintained and up to 1.0 degrees C separated temperature measurements at sites such as liver and bone marrow. These persistent temperature gradients must be borne in mind when evaluating tumor response in patients subjected to whole-body heating for disseminated cancer. Temperatures recorded by rectal, deep esophageal, or tympanic membrane sensors provided a reliable index of core temperature (including brain temperature) under equilibrium conditions at 42 degrees C, but only esophageal and tympanic sensors could safely be used to monitor the induction phase of hyperthermia and the adjustive changes in body-heat content required to stabilize core temperature during sustained hyperthermia. Pigs withstood repeated heating at 42 degrees C for 6 h, and recovered rapidly, but died after 24 h of hyperthermia. Pigs subjected to unrestrained heating died at 45 degrees C (esophagus).
在成年猪中，通过热敏电阻同时测量多个深部身体部位和外周部位的温度，这些猪在42摄氏度（直肠温度）及以上持续加热4至24小时。在体温过高期间，不同体温之间的关系得以维持，肝脏和骨髓等部位的温度测量差值可达1.0摄氏度。在评估因播散性癌症接受全身加热的患者的肿瘤反应时，必须牢记这些持续存在的温度梯度。在42摄氏度的平衡条件下，直肠、深部食管或鼓膜传感器记录的温度可提供核心温度（包括脑温）的可靠指标，但只有食管和鼓膜传感器可安全用于监测体温过高的诱导阶段以及在持续体温过高期间稳定核心温度所需的身体热量含量的调节变化。猪能耐受42摄氏度重复加热6小时，并迅速恢复，但在体温过高24小时后死亡。不受限制加热的猪在45摄氏度（食管温度）时死亡。
