组蛋白激酶与细胞分裂。
Histone kinase and cell division.
作者信息
Pawse A R, Ord M G, Stocken L A
出版信息
Biochem J. 1971 May;122(5):713-9. doi: 10.1042/bj1220713.
Abstract
- The activity of the soluble phosphokinase for histone F1 increases in regenerating rat liver during the first period of DNA synthesis after partial hepatectomy. The increase probably represents new enzyme synthesis. 2. A dose of 500rd of gamma-irradiation given early in G1 decreases the amount of histone F1 phosphokinase found 22h after partial hepatectomy by 60-70%. 3. The enzyme preparations also contained a histone F1 phosphatase; the presence together of the kinase and phosphatase caused a disproportion between net (31)P uptake and (32)P incorporation into histone F1. 4. All four subclasses of histone F1 could accept phosphate from ATP. 5. Crude enzyme preparations transferred more (31)P into histone F1 with an initially low phosphate content than into one with a high phosphate content; conversely, more (32)P was transferred into the latter.
摘要
- 在部分肝切除术后DNA合成的第一阶段，大鼠再生肝中组蛋白F1可溶性磷酸激酶的活性增加。这种增加可能代表新酶的合成。2. 在G1期早期给予500拉德的γ射线照射，可使部分肝切除术后22小时发现的组蛋白F1磷酸激酶量减少60%至70%。3. 酶制剂中还含有组蛋白F1磷酸酶；激酶和磷酸酶同时存在导致净（31）P摄取与（32）P掺入组蛋白F1之间不成比例。4. 组蛋白F1的所有四个亚类都可以从ATP接受磷酸基团。5. 粗酶制剂将更多的（31）P转移到初始磷酸盐含量低的组蛋白F1中，而不是转移到磷酸盐含量高的组蛋白F1中；相反，更多的（32）P被转移到后者中。
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本文引用的文献
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2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Disk electrophoresis of basic proteins and peptides on polyacrylamide gels.碱性蛋白质和肽在聚丙烯酰胺凝胶上的圆盘电泳。
Nature. 1962 Jul 21;195:281-3. doi: 10.1038/195281a0.
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