铁过载相关病症中肝脏铁浓度与组织化学分级及可螯合体内总铁的关系。
Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload.
作者信息
Walker R J, Miller J P, Dymock I W, Shilkin K B, Williams R
出版信息
Gut. 1971 Dec;12(12):1011-4. doi: 10.1136/gut.12.12.1011.
Abstract
A simple method based on atomic absorption spectrophotometry and using protein concentration as the reference standard was used for measuring the total tissue iron concentration in needle liver biopsy specimens from 47 patients with varying levels of body iron stores. The values obtained showed a close correlation over a wide range with measurements of total chelatable body iron stores. A comparison with the histochemical assessment of iron deposition showed that only those with grades 3 and 4 had significant increases in iron concentration which is in accord with other clinical observations in such patients. A liver biopsy can thus be of value in the quantitative determination of total body iron overload as well as in the diagnosis of underlying liver disease.
摘要
一种基于原子吸收分光光度法并以蛋白质浓度作为参考标准的简单方法，被用于测量47例体内铁储存水平各异患者的肝脏穿刺活检标本中的总组织铁浓度。所获得的值在很宽的范围内与可螯合的体内总铁储存量的测量结果密切相关。与铁沉积的组织化学评估结果相比，发现只有3级和4级患者的铁浓度有显著升高，这与对此类患者的其他临床观察结果一致。因此，肝脏活检对于定量测定全身铁过载以及诊断潜在的肝脏疾病都具有价值。
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