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1
Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload.铁过载相关病症中肝脏铁浓度与组织化学分级及可螯合体内总铁的关系。
Gut. 1971 Dec;12(12):1011-4. doi: 10.1136/gut.12.12.1011.
2
Evaluation of fine-needle aspiration biopsy smears in the diagnosis of liver iron overload.细针穿刺活检涂片在肝铁过载诊断中的评估
Acta Med Scand. 1969 Nov;186(5):369-73. doi: 10.1111/j.0954-6820.1969.tb01489.x.
3
Iron overload in patients with chronic hepatitis C virus infection: clinical and histological study.丙型肝炎病毒慢性感染患者的铁过载：临床与组织学研究
J Gastroenterol Hepatol. 2005 Feb;20(2):243-8. doi: 10.1111/j.1440-1746.2004.03549.x.
4
Quantitative measurement of iron stores with diethylenetriamine penta-acetic acid.用二乙三胺五乙酸对铁储备进行定量测量。
Gut. 1970 Nov;11(11):891-8. doi: 10.1136/gut.11.11.891.
5
Hepatic iron concentration and total body iron stores in thalassemia major.重型地中海贫血患者的肝脏铁浓度和全身铁储存量。
N Engl J Med. 2000 Aug 3;343(5):327-31. doi: 10.1056/NEJM200008033430503.
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Serum ferritin iron in iron overload and liver damage: correlation to body iron stores and diagnostic relevance.铁过载和肝损伤中的血清铁蛋白铁：与机体铁储存的相关性及诊断意义
J Lab Clin Med. 2000 May;135(5):413-8. doi: 10.1067/mlc.2000.106456.
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Myocardial iron grading by endomyocardial biopsy. A clinico-pathologic study on iron overloaded patients.通过心内膜心肌活检进行心肌铁分级。对铁过载患者的临床病理研究。
Eur J Haematol. 1989 Apr;42(4):382-8. doi: 10.1111/j.1600-0609.1989.tb01229.x.
8
Determination of tissue iron and ferritin in liver pathology comparison of histochemical and biochemical results.肝脏病理学中组织铁和铁蛋白的测定：组织化学与生化结果的比较
J Clin Chem Clin Biochem. 1989 Jun;27(6):345-9. doi: 10.1515/cclm.1989.27.6.345.
9
Significance for the diagnosis of iron overload of histochemical and chemical iron in the liver of control subjects.对照受试者肝脏中组织化学铁和化学铁对铁过载诊断的意义。
J Clin Pathol. 1968 Jan;21(1):35-40. doi: 10.1136/jcp.21.1.35.
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Fine-needle aspiration biopsy for the measurement of hepatic iron concentration.用于测量肝脏铁浓度的细针穿刺活检
Hepatology. 1992 Mar;15(3):502-6. doi: 10.1002/hep.1840150324.

引用本文的文献

1
Iron and Liver Disease.铁与肝脏疾病
Adv Exp Med Biol. 2025;1480:237-252. doi: 10.1007/978-3-031-92033-2_16.
2
Secondary Iron Overload and the Liver: A Comprehensive Review.继发性铁过载与肝脏：综述
J Clin Transl Hepatol. 2023 Aug 28;11(4):932-941. doi: 10.14218/JCTH.2022.00420. Epub 2023 Feb 1.
3
Liver iron concentration, stainable iron, and total body storage iron.肝脏铁浓度、可染铁和体内总铁储存量。
Gut. 1974 May;15(5):411-5. doi: 10.1136/gut.15.5.411.
4
Electron-microscopic and radioiron studies of iron uptake in newborn rat myocardial cells in vitro.新生大鼠心肌细胞体外铁摄取的电子显微镜和放射性铁研究。
Am J Pathol. 1981 Feb;102(2):151-9.
5
Hepatic iron in dialysed patients given intravenous iron dextran.接受静脉注射右旋糖酐铁的透析患者的肝脏铁含量
J Clin Pathol. 1990 Feb;43(2):119-24. doi: 10.1136/jcp.43.2.119.
6
Familial iron storage disease in two sisters.两姐妹的家族性铁储存疾病。
Proc R Soc Med. 1976 Nov;69(11):806-7. doi: 10.1177/003591577606901105.
7
The detection of early hemochromatosis.早期血色素沉着症的检测
Am J Dig Dis. 1978 Apr;23(4):377-9. doi: 10.1007/BF01072426.
8
Variation in the distribution of two human heart ferritin species. Isoferritin profile and subunit composition in normal and iron-overloaded subjects.两种人心脏铁蛋白种类分布的差异。正常和铁过载受试者的铁蛋白图谱及亚基组成。
Biochem J. 1977 Oct 1;167(1):309-12. doi: 10.1042/bj1670309.

本文引用的文献

1
Hepatic pathology in relatives of patients with haemochromatosis.血色素沉着症患者亲属的肝脏病理学
J Pathol Bacteriol. 1962 Jul;84:53-64.
2
DIFFERENTIAL FERRIOXAMINE TEST FOR MEASURING CHELATABLE BODY IRON.用于测量可螯合体内铁的去铁胺差异试验。
J Clin Pathol. 1965 Jan;18(1):88-97. doi: 10.1136/jcp.18.1.88.
3
The inheritance of idiopathic haemochromatosis. A clinical and liver biopsy study of 16 families.特发性血色素沉着症的遗传。对16个家族的临床及肝脏活检研究
Q J Med. 1962 Jul;31:249-65.
4
Significance for the diagnosis of iron overload of histochemical and chemical iron in the liver of control subjects.对照受试者肝脏中组织化学铁和化学铁对铁过载诊断的意义。
J Clin Pathol. 1968 Jan;21(1):35-40. doi: 10.1136/jcp.21.1.35.
5
Quantitative measurement of iron stores with diethylenetriamine penta-acetic acid.用二乙三胺五乙酸对铁储备进行定量测量。
Gut. 1970 Nov;11(11):891-8. doi: 10.1136/gut.11.11.891.
6
Iron overload in haemochromatosis.血色素沉着症中的铁过载。
Proc R Soc Med. 1970 Dec;63(12):1227-30. doi: 10.1177/003591577006301206.
7
Iron storage in alcoholic fatty liver.酒精性脂肪肝中的铁储存
Acta Med Scand. 1971 Jun;189(6):541-6. doi: 10.1111/j.0954-6820.1971.tb04419.x.
8
Improved liver-biopsy needle.改良肝活检针。
Lancet. 1969 Dec 13;2(7633):1283. doi: 10.1016/s0140-6736(69)90814-9.
9
The differential ferrioxamine test in the management of idiopathic haemochromatosis.去铁胺鉴别试验在特发性血色素沉着症管理中的应用
Lancet. 1969 Aug 23;2(7617):402-5. doi: 10.1016/s0140-6736(69)90112-3.
10
Assessment of body-iron stores in cirrhosis and haemochromatosis with the differential ferrioxamine test.用去铁胺鉴别试验评估肝硬化和血色素沉着症患者体内的铁储备情况。
Lancet. 1967 Jan 21;1(7482):133-6. doi: 10.1016/s0140-6736(67)91035-5.

铁过载相关病症中肝脏铁浓度与组织化学分级及可螯合体内总铁的关系。

Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload.

作者信息

Walker R J, Miller J P, Dymock I W, Shilkin K B, Williams R

出版信息

Gut. 1971 Dec;12(12):1011-4. doi: 10.1136/gut.12.12.1011.

DOI:10.1136/gut.12.12.1011
PMID:5157130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411991/
Abstract

A simple method based on atomic absorption spectrophotometry and using protein concentration as the reference standard was used for measuring the total tissue iron concentration in needle liver biopsy specimens from 47 patients with varying levels of body iron stores. The values obtained showed a close correlation over a wide range with measurements of total chelatable body iron stores. A comparison with the histochemical assessment of iron deposition showed that only those with grades 3 and 4 had significant increases in iron concentration which is in accord with other clinical observations in such patients. A liver biopsy can thus be of value in the quantitative determination of total body iron overload as well as in the diagnosis of underlying liver disease.

摘要

一种基于原子吸收分光光度法并以蛋白质浓度作为参考标准的简单方法，被用于测量47例体内铁储存水平各异患者的肝脏穿刺活检标本中的总组织铁浓度。所获得的值在很宽的范围内与可螯合的体内总铁储存量的测量结果密切相关。与铁沉积的组织化学评估结果相比，发现只有3级和4级患者的铁浓度有显著升高，这与对此类患者的其他临床观察结果一致。因此，肝脏活检对于定量测定全身铁过载以及诊断潜在的肝脏疾病都具有价值。