Bomford A, Lis Y, McFarlane I G, Williams R
Biochem J. 1977 Oct 1;167(1):309-12. doi: 10.1042/bj1670309.
On polyacrylamide slab electrophoresis two ferritin species, termed fast and slow, were present in three control and four iron-loaded human hearts. The ratio of the fast to slow species varied between hearts and correlated with the distribution of isoferritins, which had pI values ranging from 4.8 to 5.6. The acidic isoferritins were prominent in all hearts, but one control and the four iron-loaded hearts contained, in addition, basic isoferritins. All ferritins were composed of two subunits, an acidic H type and a more basic HL type, which was the main subunit in normal liver. Hearts with the highest proportions of acidic isoferritin contained the highest proportion of the H subunit.
在聚丙烯酰胺平板电泳中，在三个对照人心脏和四个铁负荷人心脏中存在两种铁蛋白种类，分别称为快型和慢型。快型与慢型铁蛋白的比例在心脏之间有所不同，并且与等铁蛋白的分布相关，等铁蛋白的pI值范围为4.8至5.6。酸性等铁蛋白在所有心脏中都很突出，但一个对照心脏和四个铁负荷心脏中还含有碱性等铁蛋白。所有铁蛋白均由两个亚基组成，一个酸性H型亚基和一个碱性更强的HL型亚基，HL型亚基是正常肝脏中的主要亚基。酸性等铁蛋白比例最高的心脏中H亚基的比例也最高。
