来自正常兔免疫球蛋白G重链N端半段的两个大肽段的部分序列。
The partial sequence of two large peptides from the N-terminal half of heavy chains from normal rabbit immunoglobulin G.
作者信息
Cebra J J, Steiner L A, Porter R R
出版信息
Biochem J. 1968 Mar;107(1):79-88. doi: 10.1042/bj1070079.
Abstract
The partial amino acid sequence of two large peptides is described. These were prepared from the N-terminal half of the heavy chain of immunoglobulin G from pooled normal rabbit serum by tryptic digestion after the in-amino groups of the lysine residues had been blocked with S-ethyl trifluorothioacetate. These peptides are believed to account for about 145 residues of fragment C-1, the N-terminal section of rabbit immunoglobulin G heavy chain prepared by cyanogen bromide cleavage. The evidence from the present paper and the preceding paper (Cebra, Givol & Porter, 1968) suggests that it may be possible to deduce a predominant amino acid sequence for most, if not all, of this section of the molecule.
摘要
本文描述了两种大肽的部分氨基酸序列。这些肽是通过用S-乙基三氟硫代乙酸酯封闭赖氨酸残基的氨基后，对来自混合正常兔血清的免疫球蛋白G重链的N端一半进行胰蛋白酶消化制备的。据信这些肽约占通过溴化氰裂解制备的兔免疫球蛋白G重链N端部分C-1片段的145个残基。本文及前文（Cebra、Givol和Porter，1968年）的证据表明，对于该分子的这一部分，即使不是全部，也有可能推导出大部分的主要氨基酸序列。
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本文引用的文献
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Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80.
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The kinetics of hydrazinolysis of simple peptides in anhydrous hydrazine.简单肽在无水肼中肼解的动力学
Biochem J. 1958 Mar;68(3):475-82. doi: 10.1042/bj0680475.
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Biochem J. 1967 Nov;105(2):417-26. doi: 10.1042/bj1050417.
5
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Biochem J. 1968 Mar;107(1):69-77. doi: 10.1042/bj1070069.
6
Cyanogen bromide cleavage and partial sequence of the heavy chain of a pathological immunoglobulin G.病理免疫球蛋白G重链的溴化氰裂解及部分序列分析
Biochem J. 1967 Aug;104(2):616-26. doi: 10.1042/bj1040616.
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Studies on the amino acid sequence of heavy chains from rabbit immunoglobulin G.
Proc R Soc Lond B Biol Sci. 1966 Nov 22;166(1003):159-75. doi: 10.1098/rspb.1966.0091.
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