Turton C W, Morris L, Buckingham J A, Lawler S D, Turner-Warwick M
Thorax. 1979 Oct;34(5):670-6. doi: 10.1136/thx.34.5.670.
One hundred and twenty-two patients with intrinsic asthma, extrinsic atopic asthma, or asthma with allergic bronchopulmonary aspergillosis were tissue typed for the HLA A, B, and C loci. No associations were found with any of the clinical groups, or with serum total IgE concentrations. Sixty-eight members of 10 families where more than one member was affected by asthma were studied. The segregation of haplotypes in siblings of the propositi who were or were not affected by asthma did not differ from the predicted segregation, and there were no differences when atopy or serum total IgE were considered. No biologically important association between HLA and asthma has been shown.
对122例内源性哮喘、外源性特应性哮喘或合并变应性支气管肺曲霉病的哮喘患者进行了HLA A、B和C位点的组织分型。未发现与任何临床组或血清总IgE浓度存在关联。对10个家庭中68名成员进行了研究，这些家庭中有一名以上成员患有哮喘。先证者中患或未患哮喘的同胞单倍型分离情况与预测的分离情况并无差异，考虑特应性或血清总IgE时也无差异。尚未发现HLA与哮喘之间存在具有生物学重要意义的关联。
