威克汉姆原藻的脂质组成及其对膜活性抗菌剂的敏感性
Lipid composition and sensitivity of Prototheca wickerhamii to membrane-active antimicrobial agents.
作者信息
Sud I J, Feingold D S
出版信息
Antimicrob Agents Chemother. 1979 Oct;16(4):486-90. doi: 10.1128/AAC.16.4.486.
Abstract
The lipid composition of Prototheca wickerhamii ATCC 16529 is presented and discussed in relation to the unique susceptibility of the organism to drugs of three membrane-active antimicrobial classes: the polyenes, the polymyxins, and the imidazoles. The presence of ergosterol in the neutral lipid fraction of the membrane is likely responsible for the exquisite susceptibility to amphotericin B. The presence of a large quantity of free fatty acids in the membrane appears responsible for imidazole susceptibility. The membrane determinants of polymyxin B susceptibility are less well defined.
摘要
本文展示并讨论了威克海姆原藻ATCC 16529的脂质组成，该生物对三种膜活性抗菌药物（多烯类、多粘菌素类和咪唑类）具有独特的敏感性。膜中性脂质部分中麦角固醇的存在可能是其对两性霉素B高度敏感的原因。膜中大量游离脂肪酸的存在似乎是其对咪唑敏感的原因。多粘菌素B敏感性的膜决定因素尚不太明确。
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