犬肝脏中丙氨酸-乙醛酸氨基转移酶和丝氨酸-丙酮酸氨基转移酶的亚细胞分布
The subcellular distribution of alanine-glyoxylate aminotransferase and serine-pyruvate aminotransferase in dog liver.
作者信息
Okuno E, Minatogawa Y, Nakanishi J, Nakamura M, Kamoda N, Makino M, Kido R
出版信息
Biochem J. 1979 Sep 15;182(3):877-9. doi: 10.1042/bj1820877.
Abstract
The subcellular distributions of alanine-glyoxylate aminotransferase and serine-pyruvate aminotransferase in the particulate fraction of dog liver were examined by centrifugation in a sucrose density gradient. Most of both enzyme activities in the particulate fraction were localized in the mitochondria, but not in the peroxisomes.
摘要
通过在蔗糖密度梯度中离心，研究了犬肝微粒体部分中丙氨酸-乙醛酸氨基转移酶和丝氨酸-丙酮酸氨基转移酶的亚细胞分布。微粒体部分中这两种酶的大部分活性都定位于线粒体中，而非过氧化物酶体中。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Studies on the metabolism of hydroxypyruvate in animal tissues.动物组织中羟基丙酮酸代谢的研究。
Biochem J. 1959 Jul;72(3):496-508. doi: 10.1042/bj0720496.
3
Tissue fractionation studies. 12. Intracellular distribution of some dehydrogenases, alkaline deoxyribonuclease and iron in rat-liver tissue.组织分级分离研究。12. 大鼠肝脏组织中某些脱氢酶、碱性脱氧核糖核酸酶和铁的细胞内分布。
Biochem J. 1959 Dec;73(4):623-8. doi: 10.1042/bj0730623.
4
Liver-L-alanine-glyoxylate and L-serine-pyruvate aminotransferase activities: an apparent association with gluconeogenesis.肝脏L-丙氨酸-乙醛酸和L-丝氨酸-丙酮酸转氨酶活性：与糖异生的明显关联。
Biochem J. 1969 Dec;115(5):1071-3. doi: 10.1042/bj1151071.
5
Biosynthesis of the wall teichoic acid in Bacillus licheniformis.地衣芽孢杆菌中壁磷壁酸的生物合成。
Biochem J. 1972 Mar;127(1):27-37. doi: 10.1042/bj1270027.
6
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7
Increased liver L-serine-pyruvate aminotransferase activity under gluconeogenic conditions.在糖异生条件下肝脏L-丝氨酸-丙酮酸转氨酶活性增加。
Biochem J. 1973 May;134(1):349-51. doi: 10.1042/bj1340349.
8
Colorimetric assay of catalase.过氧化氢酶的比色测定
Anal Biochem. 1972 Jun;47(2):389-94. doi: 10.1016/0003-2697(72)90132-7.
9
Pathways of gluconeogenesis from L-serine in the neonatal rat.新生大鼠中由L-丝氨酸生成葡萄糖的途径。
Biochem J. 1974 Aug;142(2):433-6. doi: 10.1042/bj1420433.
10
Regulation of hepatic L-serine dehydratase and L-serine-pyruvate aminotransferase in the developing neonatal rat.新生大鼠发育过程中肝脏L-丝氨酸脱水酶和L-丝氨酸-丙酮酸转氨酶的调节
Biochem J. 1974 Dec;144(3):519-31. doi: 10.1042/bj1440519.
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