关于经亚致死剂量照射的小鼠腹腔巨噬细胞免疫重建的研究。
Studies on the immune reconstitution of sublethally irradiated mice by peritoneal macrophages.
作者信息
Gershon H, Feldman M
出版信息
Immunology. 1968 Dec;15(6):827-35.
Studies were performed on the reconstitution of the immune response to and sheep erythrocytes in sublethally irradiated mice by the injection of normal peritoneal macrophages with and without pre-incubation with antigen. The response to was found to be less radiosensitive than the anti-SRBC response. Sublethally irradiated mice (550 r) injected with peritoneal macrophages from normal donors pre-incubated with antigen or injected simultaneously with macrophages and evinced a strong anti- response. No such reconstitution of the immune response against SRBC was observed, even when lower irradiation doses and phagocytosis-enhancing incubation media were used. Possible reasons for the different response to and SRBC are discussed.
通过向亚致死剂量照射的小鼠注射正常腹腔巨噬细胞（有无抗原预孵育），对小鼠针对[抗原名称未给出]和绵羊红细胞的免疫反应重建进行了研究。发现针对[抗原名称未给出]的反应比对抗绵羊红细胞反应的放射敏感性低。给亚致死剂量照射（550拉德）的小鼠注射与[抗原名称未给出]抗原预孵育的正常供体腹腔巨噬细胞，或同时注射巨噬细胞和[抗原名称未给出]，表现出强烈的抗[抗原名称未给出]反应。即使使用较低的照射剂量和增强吞噬作用的孵育培养基，也未观察到针对绵羊红细胞的免疫反应有这种重建情况。讨论了对[抗原名称未给出]和绵羊红细胞反应不同的可能原因。
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