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动脉内氧分压电极的扫描电子显微镜检查(作者译)

[Scanning electron microscopic examination of intra-arterial PO2 electrodes (author's transl)].

作者信息

Goeckenjan G, Lenz W

出版信息

Klin Wochenschr. 1979 Nov 15;57(22):1217-23. doi: 10.1007/BF01489249.

DOI:10.1007/BF01489249
PMID:522424
Abstract

Continuous blood gas measurement by means of indwelling intraarterial electrodes facilitates and contributes to considerably improve the monitoring of pulmonary gas exchange in intensive care and anaesthesiology. Knowledge of the behaviour of the electrode surface in the blood stream is necessary to assess the characteristics of the measuring and the possible risks or complications. Scanning electron microscopic examinations were performed in a commercial-type polarographic PO2 electrode after in vitro and in vivo application. 14 electrodes were examined after continuous intra-arterial measurements in patients with chronic obstructive pulmonary disease and in intensive care patients. Duration of intra-arterial measurements was 2-109 h. Already after a measuring period of 2 h in nearly all cases a protein film was discovered on the electrode surface. Microthrombotic deposits were seen in 2 cases, in one of these despite of treatment with heparin. The electrode membrane showed a network ofmicro-cracks, small bubbles and dents. The membrane changes were probably the result of the drying process during the electron microscopic preparation, because the membrane material (Hydron) is hydrophil and swells during the measurement. Yet it cannot be excluded that these changes occur, in part, during the measurements. From these and other studies we conclude that the intra-arterial application of this electrode has a low risk of thromboembolic complications. The deposits on the electrode surface and the membrane changes may probably affect the response time and possibly also the stability of the electrode.

摘要

通过留置动脉内电极进行连续血气测量有助于并极大地促进了重症监护和麻醉中肺气体交换监测的改善。了解电极表面在血流中的行为对于评估测量特性以及可能的风险或并发症是必要的。在体外和体内应用后,对一种商用型极谱PO2电极进行了扫描电子显微镜检查。在慢性阻塞性肺疾病患者和重症监护患者中进行连续动脉内测量后,对14个电极进行了检查。动脉内测量持续时间为2至109小时。几乎在所有情况下,在测量2小时后,电极表面就发现了一层蛋白质膜。在2例中观察到微血栓沉积,其中1例尽管使用了肝素治疗。电极膜显示出微裂纹、小气泡和凹痕的网络。膜的变化可能是电子显微镜制备过程中干燥过程的结果,因为膜材料(Hydron)是亲水的,在测量过程中会膨胀。然而,不能排除这些变化部分发生在测量期间。从这些研究和其他研究中我们得出结论,该电极的动脉内应用血栓栓塞并发症风险较低。电极表面的沉积物和膜的变化可能会影响响应时间,也可能影响电极的稳定性。

相似文献

1
[Scanning electron microscopic examination of intra-arterial PO2 electrodes (author's transl)].动脉内氧分压电极的扫描电子显微镜检查(作者译)
Klin Wochenschr. 1979 Nov 15;57(22):1217-23. doi: 10.1007/BF01489249.
2
Continuous intra-arterial PO2 monitoring with a surface heparinized catheter electrode. A study of conformity in conventional blood gas analysis and of long-term electrode function in the non-heparinized dog.使用表面肝素化导管电极进行连续动脉内氧分压监测。对传统血气分析的一致性以及非肝素化犬长期电极功能的研究。
Scand J Clin Lab Invest. 1982 Jun;42(4):331-8.
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Transcutaneous pO2 electrode.经皮氧分压电极
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Polarographic pO2 sensors with heparinized membranes for in vitro and continuous in vivo registration.带有肝素化膜的极谱氧分压传感器,用于体外和体内连续记录。
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Resuscitation. 1978;6(3):207-14. doi: 10.1016/s0300-9572(78)80015-x.
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A fast responding intra-arterial pH electrode for use in the peripheral artery of adult humans and large mammals: a technical development for use in research.
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[Polarographic measurements of PO2 with a 95% response time of 7-10 msec (author's transl)].用极谱法测量氧分压,95%响应时间为7 - 10毫秒(作者译)
Respiration. 1978;35(1):8-14. doi: 10.1159/000193853.
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[Transcutaneous measurement of partial pressure of oxygen in paediatric intensive care (author's transl)].小儿重症监护中经皮氧分压测量(作者译)
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本文引用的文献

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Biologic compatibility and applications of hydron.聚羟亚乙基的生物相容性及其应用
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Continuous intra-arterial P O2 measurements in infants.婴儿动脉血氧分压的连续测量
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Laboratory and clinical evaluation of a new indwelling oxygen electrode for continuous monitoring of PaO2 in neonates.一种用于持续监测新生儿动脉血氧分压(PaO2)的新型留置式氧电极的实验室及临床评估。
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