Heinrich H C, Gabbe E E, Icagić F
Klin Wochenschr. 1979 Nov 15;57(22):1237-8. doi: 10.1007/BF01489252.
Immunoreactive serum trypsin was measured with a double antibody radioimmunoassay in normal subjects and patients with various diseases of the pancreas. The normal range is 115-350 ng/ml with a geometric mean of 212 ng/ml. No trypsin was found in serum after total duodenopancreatectomy, in about 75% of patients with cystic fibrosis and in a few patients with pancreas carcinoma or chronic pancreatitis. Reduced serum trypsin levels between 10 and 100 ng/ml were measured in the remaining 25% of cystic fibrosis and in one third of the patients with chronic pancreatitis. Serum trypsin was increased to 700-17,000 ng/ml in all patients with acute pancreatitis or during the acute phase of chronic pancreatitis. Absent or reduced serum trypsin is a reliable indicator of total or partial exocrine pancreatic insufficiency whereas considerably increased serum trypsin concentration do indicate acute pancreatitis.
采用双抗体放射免疫分析法测定了正常人和患有各种胰腺疾病患者血清中的免疫反应性胰蛋白酶。正常范围为115 - 350 ng/ml，几何平均值为212 ng/ml。在全十二指肠胰腺切除术后的患者血清中未发现胰蛋白酶，约75%的囊性纤维化患者以及少数胰腺癌或慢性胰腺炎患者血清中也未发现胰蛋白酶。其余25%的囊性纤维化患者以及三分之一的慢性胰腺炎患者血清胰蛋白酶水平降低至10 - 100 ng/ml。所有急性胰腺炎患者或慢性胰腺炎急性期患者的血清胰蛋白酶水平升高至700 - 17,000 ng/ml。血清胰蛋白酶缺失或降低是胰腺外分泌功能完全或部分不全的可靠指标，而血清胰蛋白酶浓度显著升高则表明患有急性胰腺炎。
