雌雄嵌合体的单侧模式神经活动，果蝇一种神经突变体的嵌合体。
Unilaterally patterned neural activity of gynandromorphs, mosaic for a neurological mutant of Drosophila melanogaster.
作者信息
Ikeda K, Kaplan W D
出版信息
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1480-7. doi: 10.1073/pnas.67.3.1480.
A neurophysiological study of a behavioral phenotype caused by a sex-linked single gene mutation has been performed with gynandromorphs, mosaic for the mutant gene, Hyperkinetic(1P) (Hk(1P)), in Drosophila melanogaster. The male tissue of this gynandromorph is hemizygous for Hk(1P), while the female tissue is heterozygous. The characteristic neural activity caused by the Hk(1P) gene can be recorded only in the presumptive male region of the thoracic ganglion. Motor regions of one side were found to function independently of their counterparts in the opposite side of the thoracic ganglion and were unaffected by the genotype of other parts of the body. Thus, expression of the Hk(1P) gene is autonomous in the genetic sense, and each side of the ganglion is independent of the other side. Also, there is a high correlation between the external genotype and the genotype of underlying neural tissue of the thorax.
利用果蝇双性嵌合体对一种由性连锁单基因突变引起的行为表型进行了神经生理学研究。这种双性嵌合体镶嵌有突变基因“多动（1P）”（Hk（1P））。该双性嵌合体的雄性组织对于Hk（1P）是半合子，而雌性组织是杂合子。由Hk（1P）基因引起的特征性神经活动仅能在胸神经节的假定雄性区域记录到。发现一侧的运动区域独立于胸神经节另一侧的对应区域发挥功能，并且不受身体其他部位基因型的影响。因此，从遗传学意义上讲，Hk（1P）基因的表达是自主的，神经节的每一侧都独立于另一侧。此外，外部基因型与胸部潜在神经组织的基因型之间存在高度相关性。
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