Michalski J P, Daniels T E, Talal N, Grey H M
N Engl J Med. 1975 Dec 11;293(24):1228-31. doi: 10.1056/NEJM197512112932404.
We measured salivary beta2 microglobulin concentrations in 49 patients evaluated for Sjögren's syndrome with a labial salivary-gland biopsy. The salivary concentration was elevated and a significant correlation (P less than 0.001) was found between the concentration and the degree of inflammation seen in the biopsy. Serum concentrations were increased in 135 patients with Sjögren's syndrome. Striking elevations were seen in patients with associated renal or lymphoproliferative complications. Three patients have an increase in serum beta2 microglobulin concentration in association with exacerbation of their disease, and six a decrease after clinically efficacious therapy. These data indicate that determination of beta2 microglobulin in saiva may provide a simple, noninvasive technic for estimation of the degree of local inflammation in autoimmune disease.
我们对49例因干燥综合征接受唇唾液腺活检评估的患者测量了唾液β2微球蛋白浓度。唾液浓度升高，且在活检中发现该浓度与炎症程度之间存在显著相关性（P<0.001）。135例干燥综合征患者的血清浓度升高。在伴有肾脏或淋巴增殖性并发症的患者中出现显著升高。3例患者疾病加重时血清β2微球蛋白浓度升高，6例经临床有效治疗后降低。这些数据表明，测定唾液中的β2微球蛋白可能为评估自身免疫性疾病局部炎症程度提供一种简单、非侵入性的技术。
