Talal N, Grey H M, Zvaifler N, Michalski J P, Daniels T E
Science. 1975 Mar 28;187(4182):1196-8. doi: 10.1126/science.46621.
Beta2-Microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, elevated concentrations of beta2--microglobulin were found in saliva and synovial fluid from patients with Sjogren's syndrome and rheumatoid arthritis, autoimmune inflammatory diseases that attack and destroy the salivary glands and articular tissues, respectively. Elevated beta2-microglobulin concentrations decreased in the saliva of two patients who simultaneously showed a clinical response to systemic treatment. Measurement of beta2-microglobulin in inflammatory fluids may offer a simple method of quantifying local activity in autoimmune states.
β2-微球蛋白通常以低浓度存在于血清和其他体液中。通过放射免疫测定法发现，干燥综合征和类风湿关节炎患者的唾液和滑液中β2-微球蛋白浓度升高，这两种自身免疫性炎症疾病分别攻击并破坏唾液腺和关节组织。两名同时对全身治疗有临床反应的患者，其唾液中升高的β2-微球蛋白浓度降低。测定炎症液中的β2-微球蛋白可能提供一种量化自身免疫状态下局部活动的简单方法。
