鹅膏蕈碱对流感病毒复制的抑制作用：作用模式
Inhibition of influenza virus replication by -amanitin: mode of action.
作者信息
Mahy B W, Hastie N D, Armstrong S J
出版信息
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1421-4. doi: 10.1073/pnas.69.6.1421.
Abstract
The replication of influenza virus in chick embryo fibroblast cells is inhibited by alpha-amanitin added during the first 2 hr of infection at concentrations similar to those required to inhibit cellular DNA-dependent RNA polymerase form II in vivo. Of two periods of increased RNA synthesis observed in cells infected with influenza virus, only the first, occurring from 0 to 2 hr after infection, is sensitive to alpha-amanitin. During this early period, there is a stimulation of the activity of DNA-dependent RNA polymerase II of nuclei isolated from infected cells. The data suggest that DNA transcription mediated by polymerase II is essential for influenza virus replication.
摘要
在感染的最初2小时内添加α-鹅膏蕈碱，可抑制流感病毒在鸡胚成纤维细胞中的复制，其所需浓度与体内抑制细胞DNA依赖性RNA聚合酶II所需浓度相似。在感染流感病毒的细胞中观察到两个RNA合成增加的时期，只有第一个时期（感染后0至2小时）对α-鹅膏蕈碱敏感。在这个早期阶段，感染细胞分离出的细胞核中DNA依赖性RNA聚合酶II的活性受到刺激。数据表明，由聚合酶II介导的DNA转录对于流感病毒复制至关重要。
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