与急性白血病相关抗原的检测。
Detection of an antigen associated with acute leukemia.
作者信息
Mann D L, Rogentine G N, Halterman R, Leventhal B
出版信息
Science. 1971 Dec 10;174(4014):1136-7. doi: 10.1126/science.174.4014.1136.
PMID:5289583
Abstract
Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens.
摘要
用来自伯基特淋巴瘤组织培养细胞系的一种纯化细胞膜成分在兔体内制备了抗血清。这些抗血清对15例急性白血病患者中的8例以及41名亲属中的5名的外周血白细胞具有细胞毒性，但对临床缓解期白血病患者或正常个体的外周血白细胞无细胞毒性。这些抗血清似乎检测到了一种或多种与急性白血病相关的抗原。
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