Brook I, Controni G, Kassan S S, Moutsopoulos H M
J Rheumatol. 1979 Nov-Dec;6(6):691-3.
Cerebrospinal fluid (CSF) samples from 22 patients with systemic lupus erythematosus (SLE) and 20 samples from normal controls were studied for lactic acid levels. Ten samples were obtained from SLE patients with active central nervous system (CNS) involvement and 12 from SLE patients with inactive CNS disease. The mean CSF lactic acid level in patients with SLE was 17.24 +/- 1.25 mg/dl (range 31-10.2 mg/dl) which was not statistically different to the normal control mean of 14.75 +/- 0.9 mg/dl (range 9-28 mg/dl). Thus, lactic acid levels in active or inactive CNS disease of SLE appear to be normal. Due to the fact that lactic acid levels are elevated in the CSF of patients with bacterial meningitis, lactic acid levels can be of potential value in the differentiation between bacterial meningitis and CNS involvement of SLE.
对22例系统性红斑狼疮（SLE）患者的脑脊液（CSF）样本和20例正常对照样本进行了乳酸水平研究。其中10份样本来自有中枢神经系统（CNS）活动受累的SLE患者，12份来自无CNS疾病活动的SLE患者。SLE患者的脑脊液乳酸平均水平为17.24±1.25mg/dl（范围31 - 10.2mg/dl），与正常对照平均水平14.75±0.9mg/dl（范围9 - 28mg/dl）无统计学差异。因此，SLE活动或非活动CNS疾病患者的乳酸水平似乎正常。由于细菌性脑膜炎患者脑脊液中的乳酸水平会升高，乳酸水平在鉴别细菌性脑膜炎和SLE的CNS受累方面可能具有潜在价值。
