Bull World Health Organ. 1965;32(5):603-25.
In a controlled field trial on some 584 000 people in an endemic cholera El Tor area in the Philippines, it was demonstrated that cholera vaccines gave moderate protection of short duration. Injection of a single dose of vaccine prepared from either Vibrio cholerae or Vibrio El Tor gave over 50% protection for the first two months. The immunity conferred by the V. cholerae vaccine rapidly declined after three to four months. The V. El Tor vaccine gave protection for six months, but its effectiveness declined. An oil-adjuvant vaccine prepared from V. cholerae conferred an increasing degree of protection of long duration, but, owing to severe vaccination reactions, its use could not be recommended.
在菲律宾霍乱埃尔托流行区对约58.4万人进行的一项对照现场试验表明，霍乱疫苗提供了持续时间较短的适度保护。注射一剂由霍乱弧菌或埃尔托弧菌制备的疫苗，在前两个月提供了超过50%的保护。霍乱弧菌疫苗所赋予的免疫力在三到四个月后迅速下降。埃尔托弧菌疫苗提供了六个月的保护，但其效力下降。由霍乱弧菌制备的油佐剂疫苗提供了程度不断增加的长期保护，但由于严重的疫苗接种反应，不建议使用。
