Azurin J C, Alvero M
Bull World Health Organ. 1971;44(6):815-9.
From May 1964 to December 1965, a controlled field trial of the effectiveness of cholera and cholera El Tor vaccines was conducted in Negros Occidental, Philippines. Some people did not volunteer for vaccination, and of those who did some received cholera vaccine and others a control (typhoid) vaccine. After analysing he incidence of cholera among these three groups it was found that the morbidity and mortality rates were significantly higher in the unvaccinated group than in either the control vaccine group or the cholera vaccine group. This would indicate that the unvaccinated group is basically different from the vaccinated control group. The clinical course of the disease was the same whether the patient had been vaccinated or not. The reasons for non-vaccination were investigated and should be taken into account by public health agencies when immunization programmes are being planned.
1964年5月至1965年12月，在菲律宾西内格罗斯省进行了一项关于霍乱疫苗和霍乱埃尔托型疫苗有效性的对照现场试验。一些人没有自愿接种疫苗，在自愿接种的人群中，有些人接种了霍乱疫苗，其他人接种了对照（伤寒）疫苗。分析这三组人群中的霍乱发病率后发现，未接种疫苗组的发病率和死亡率显著高于对照疫苗组或霍乱疫苗组。这表明未接种疫苗组与接种疫苗的对照组存在本质差异。无论患者是否接种过疫苗，疾病的临床病程都是相同的。对未接种疫苗的原因进行了调查，公共卫生机构在规划免疫计划时应予以考虑。
