在菲律宾进行的单价传统霍乱疫苗和埃尔托霍乱疫苗有效性的对照现场试验。
A controlled field trial of the effectiveness of monovalent classical and El Tor cholera vaccines in the Philippines.
出版信息
Bull World Health Organ. 1973;49(1):13-9.
Monovalent Ogawa and Inaba vaccines prepared from classical and El Tor strains of Vibrio cholerae were field-tested in Negros Occidental, Philippines, where cholera El Tor, serotype Ogawa, is endemic. The monovalent classical Ogawa and Inaba vaccines were of the same lots as those tested in East Pakistan in 1968-69. The results indicated that all four types of vaccine tested offered significant degrees of protection varying from 58% to 71%. The Ogawa vaccines were slightly, though not significantly, more protective than the Inaba vaccines against disease caused by Ogawa. The biotypes of the vaccine strains were found to be of no consequence.
由霍乱弧菌古典生物型和埃尔托生物型菌株制备的单价小川型和稻叶型疫苗在菲律宾西内格罗斯省进行了现场试验，该地霍乱埃尔托生物型小川血清型为地方流行。单价古典生物型小川型和稻叶型疫苗与1968 - 1969年在东巴基斯坦试验的疫苗为同一批次。结果表明，所试验的所有四种疫苗均提供了显著程度的保护，保护率从58%至71%不等。在预防由小川型引起的疾病方面，小川型疫苗的保护效果略优于稻叶型疫苗，不过差异并不显著。发现疫苗菌株的生物型并无影响。
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