Factors influencing the immune response. 3. The blocking effect of Corynebacterium parvum upon the induction of acquired immunological unresponsiveness to bovine serum albumin in the adult rabbit.

The intravenous injection of 10 mg aggregate-free, centrifuged bovine albumin into adult rabbits has been shown to induce an unresponsive state to bovine serum albumin (BSA) in the majority of rabbits. An intravenous injection of 15 mg of a heat-killed suspension of either 6 days prior to or simultaneously with centrifuged bovine albumin has been shown to significantly block the induction of unresponsiveness to BSA. Some effects of upon the lymphoreticular tissues in the rabbit are reported.