Meingassner J G, Schmook F P, Czok R, Mieth H
Poult Sci. 1979 Mar;58(2):308-13. doi: 10.3382/ps.0580308.
The anticoccidial activities of monensin and lasalocid have been studied separately and in combination with tiamulin, a new pleuromutilin derivative. Combinations of constant tiamulin concentration (.0125%) in drinking water with various levels of polyether anticoccidials (6.3 to 125 ppm) in feed and conversely of constant levels of anticoccidials with various concentrations of tiamulin were used. The prophylactic efficacy of these combined treatments in battery raised broiler chickens infected with Eimeria tenella was evaluated. Assessment of the parameters mortality, weight gain, dropping scores, lesion scores, and oocyst output showed that simultaneous application of tiamulin significantly improved the anticoccidial activity of the polyethers. As tiamulin alone is without anticoccidial activity, this phenomenon was considered to result from an interaction between tiamulin and the polyethers leading to a slower metabolic degradation of the latter. Thus tissue levels adequate for maximum anticoccidial activity would be attained with lower polyether dose levels. Experiments using isolated perfused rat liver showed that elimination of monensin was reduced by 60% in the presence of tiamulin.
已分别研究了莫能菌素和拉沙洛西的抗球虫活性，并研究了它们与新型截短侧耳素衍生物泰妙菌素联合使用的情况。采用在饮用水中添加恒定浓度（0.0125%）的泰妙菌素并在饲料中添加不同水平（6.3至125 ppm）的聚醚抗球虫药，以及相反地在饲料中添加恒定水平的抗球虫药并在饮用水中添加不同浓度泰妙菌素的组合方式。评估了这些联合处理对笼养感染柔嫩艾美耳球虫的肉鸡的预防效果。对死亡率、体重增加、粪便评分、病变评分和卵囊产量等参数的评估表明，同时使用泰妙菌素可显著提高聚醚类药物的抗球虫活性。由于泰妙菌素单独使用时无抗球虫活性，因此认为这种现象是由泰妙菌素与聚醚类药物之间的相互作用导致后者代谢降解减慢所致。因此，使用较低剂量的聚醚类药物就能达到足以产生最大抗球虫活性的组织水平。使用离体灌注大鼠肝脏进行的实验表明，在有泰妙菌素存在的情况下，莫能菌素的消除率降低了60%。
