体外T和B淋巴细胞的激活：同种异体效应因子上存在β2-微球蛋白决定簇。
Activation of T and B lymphocytes in vitro: presence of beta2-microblobulin determinants on allogeneic effect factor.
作者信息
Armerding D, Kubo R T, Grey H M, Katz D H
出版信息
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4577-81. doi: 10.1073/pnas.72.11.4577.
Abstract
The biologically acitve entity termed allogeneic effect factor, which is produced by alloantigen-activated T cells and has been shown to regulate triggering and differentiation of B lymphocytes in vitro, has previously been demonstrated to possess antigenic determinants coded by genes in the I region of the H-2 gene complex of the mouse. The studies presented here provide evidence that allogeneic effect factor also possesses antigenic determinants identical or cross-reactive with beta2-microglobulin. These observations suggest an important role for beta2-microglobulin in the mechanism of cell-cell interactions and the consequences of such interactions on lymphocyte triggering and differentiation.
摘要
被称为同种异体效应因子的生物活性实体，由同种异体抗原激活的T细胞产生，且已证实在体外可调节B淋巴细胞的触发和分化，此前已证明其具有由小鼠H-2基因复合体I区基因编码的抗原决定簇。此处呈现的研究提供了证据，表明同种异体效应因子还具有与β2-微球蛋白相同或交叉反应的抗原决定簇。这些观察结果表明β2-微球蛋白在细胞间相互作用机制以及这种相互作用对淋巴细胞触发和分化的影响中起重要作用。
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本文引用的文献
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2
Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.细胞协作中的抗原特异性T细胞因子：物理性质及在H-2左手（K）半区的定位
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3
Mitogenic properties of rabbit anti-human beta 2-microglobulin for murine B cells.兔抗人β2微球蛋白对鼠B细胞的促有丝分裂特性。
Scand J Immunol. 1974;3(4):445-54. doi: 10.1111/j.1365-3083.1974.tb01277.x.
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