Toivanen P, Toivanen A, Vainio O
J Exp Med. 1974 May 1;139(5):1344-9. doi: 10.1084/jem.139.5.1344.
For transplantation of semiallogeneic bursal stem cells into cyclophosphamide-treated 3-day old chicks, two lines of chickens homozygous at the major histocompatibility locus and their F(1) hybrids were used in reciprocal combinations. The semiallogeneic transplantations resulted in a complete restoration of antibody formation to sheep red blood cells (SRBC) and Brucella, of microscopic morphology of bursa fabricii, and of germinal center formation in the spleen. In contrast, allogeneic bursal stem cells were not effective in restoring secondary response to SRBC and germinal center formation, while they were able to reconstitute anti-Brucella responses and bursal morphology. These findings indicate an effective cooperation of donor and host cells leading to a complete restoration of the bursa-dependent lymphoid system, when the donor and recipient share at least one haplotype determining the major histocompatibility antigen complex.
为了将半同种异体法氏囊干细胞移植到经环磷酰胺处理的3日龄雏鸡体内，使用了在主要组织相容性位点纯合的两个鸡系及其F(1)杂种进行相互组合。半同种异体移植导致对绵羊红细胞（SRBC）和布鲁氏菌的抗体形成、法氏囊的微观形态以及脾脏生发中心形成完全恢复。相比之下，同种异体法氏囊干细胞在恢复对SRBC的二次反应和生发中心形成方面无效，而它们能够重建抗布鲁氏菌反应和法氏囊形态。这些发现表明，当供体和受体共享至少一个决定主要组织相容性抗原复合物的单倍型时，供体细胞和宿主细胞会进行有效合作，从而使依赖法氏囊的淋巴系统完全恢复。
