Böhme H R, Richter H, Fischer P
Z Gesamte Inn Med. 1979 Oct 1;34(19):574-80.
The paper presents further investigations for a critical survey on the influences of drugs on laboratory methods. In controversion to the meanings you can find in the literature that ascorbic acid is most one of the important drugs to interfere with laboratory results we couldn't see in our systematical experimental investigation such results. Only in very extremly cases it seems to be right. Selected parameters of clinical chemistry (glucose, lactic dehydrogenase, aspartal-aminotransferase, alanine aminotransferase, alkaline phosphatase, protein, albumine, creatinine, butanol extractable iodine, ferrum) show under therapeutic conditions no influences of ascorbic acid, which can lead to diagnostic or therapeutic false interpretations. Above all the often mentioned example that glucose estimations in blood (reduction methods) can disturb if ascorbic acid is present, is abstracted in an uncritical manner how our experimental results may show.
本文针对药物对实验室检测方法影响的批判性综述展开了进一步研究。与文献中关于抗坏血酸是干扰实验室结果的最重要药物之一的观点相反，在我们系统的实验研究中并未观察到此类结果。仅在极少数极端情况下，这种说法似乎才是正确的。临床化学的选定参数（葡萄糖、乳酸脱氢酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶、蛋白质、白蛋白、肌酐、正丁醇可提取碘、铁）在治疗条件下未显示抗坏血酸有影响，而抗坏血酸的存在可能导致诊断或治疗上的错误解读。尤其是经常提到的血液中葡萄糖测定（还原法）在抗坏血酸存在时会受干扰的例子，我们的实验结果表明这种说法是缺乏严谨性的。
