Sandler M, Reynolds G P
Lancet. 1976 Jan 10;1(7950):70-1. doi: 10.1016/s0140-6736(76)90156-2.
The model psychosis associated with amphetamine overdosage is known to bear a close resemblance to acute paranoid schizophrenia. Amphetamine is chemically similar to the endogenous sympathomimetic amine, phenylethylamine, which possess many of its pharmacological properties. It is suggested that some cases of schizophrenia may be associated with an abnormal phenylethylamine response, either from increased concentrations of the amine or from abnormal receptor sensitivity to it.
已知与苯丙胺过量相关的典型精神病与急性偏执型精神分裂症极为相似。苯丙胺在化学结构上与内源性拟交感胺苯乙胺相似，苯乙胺具有许多苯丙胺的药理特性。有人提出，某些精神分裂症病例可能与苯乙胺反应异常有关，这种异常反应可能是由于该胺浓度升高，或者是由于受体对其敏感性异常所致。
