使用抗淋巴细胞血清和组织培养来研究细胞介导反应在小鼠病毒性脑炎中的作用。
Antilymphocyte serum and tissue culture used to investigate role of cell-mediated response in viral encephalitis in mice.
作者信息
Rook G A, Webb H E
出版信息
Br Med J. 1970 Oct 24;4(5729):210-2. doi: 10.1136/bmj.4.5729.210.
Abstract
Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.
摘要
给瑞士白化小鼠注射抗淋巴细胞血清以选择性抑制其对兰加特病毒的细胞反应，可延长平均存活时间。在体外，来自病毒免疫小鼠的淋巴结细胞对感染病毒的同基因非神经脑细胞具有强烈的细胞毒性。本文讨论了这些发现的意义，特别提及了自身免疫的概念。
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