Frösner G G, Deinhardt F, Scheid R, Kreiner C F, Eisenburg J
Klin Monbl Augenheilkd. 1979 Oct;175(4):502-8.
Hepatitis-B-surface antigen (HBsAg) was not detected by sensitive radioimmunoassays in the tear fluids of 6 HBsAg carriers with low and medium titers of HBsAg (less than 1:10,000) in the serum. However, HBsAg could be demonstrated in low concentrations in tear fluids of 5 of 6 HBsAg carriers with high serum titers (greater than 1:10,000). The concentration of HBsAg in the tear fluid was at least 100 times lower than in the sera of these 5 persons. Correspondingly HBsAg could be found in only 1 of the rinsing and in none of the storage solutions of the contact lenses of 7 persons with high titers of HBsAg in the serum (greater than 1:32,000). HBsAg was not adsorbed to smooth HEMA-lenses. Because of the low concentration of HBsAg in tear fluids and the dilution effect (about 5 x 10(-10)) the transmission of hepatitis B by multiple use of contact lenses by several persons during adaption is lighly unlikely. In addition, a special cleaning solution (Liprofin) can destroy nearly completely the antigenicity of HBsAg at 60 degrees C.
在血清中乙肝表面抗原（HBsAg）滴度为低和中等水平（小于1:10,000）的6名HBsAg携带者的泪液中，用灵敏的放射免疫测定法未检测到HBsAg。然而，在血清滴度高（大于1:10,000）的6名HBsAg携带者中，有5人的泪液中能检测到低浓度的HBsAg。这5人的泪液中HBsAg浓度至少比血清中低100倍。相应地，在血清中HBsAg滴度高（大于1:32,000）的7人的隐形眼镜冲洗液中仅在1份中发现了HBsAg，而在储存液中均未发现。HBsAg不会吸附到光滑的甲基丙烯酸羟乙酯（HEMA）镜片上。由于泪液中HBsAg浓度低以及稀释效应（约5×10⁻¹⁰），在适配过程中多人多次使用隐形眼镜传播乙型肝炎的可能性极小。此外，一种特殊的清洁溶液（Liprofin）在60℃时能几乎完全破坏HBsAg的抗原性。
