通过“反应性溶解”程序在游离溶液中制备的人补体第五、第六和第七成分（C567）的三分子复合物对嗜中性粒细胞和嗜酸性粒细胞的趋化活性。
The chemotactic activity for neutrophil and eosinophil leucocytes of the trimolecular complex of the fifth, sixth and seventh components of human complement (C567) prepared in free solution by the 'reactive lysis' procedure.
作者信息
Lachmann P J, Kay A B, Thompson R A
出版信息
Immunology. 1970 Dec;19(6):895-9.
Abstract
C[unk]567, prepared by the interaction of purified C[unk]56 with purified C7 in solution, has been shown to be chemotactic for neutrophils and eosinophils. This activity was not significantly affected by the presence of C8 and C9, even in substantial excess. However, if the interaction of C[unk]56 with C7 took place in the presence of an excess of erythrocytes, these cells bound the C[unk]567 and were converted to EC567; and no chemotactic factor was found.
摘要
由纯化的C[unk]56与溶液中的纯化C7相互作用制备的C[unk]567，已被证明对中性粒细胞和嗜酸性粒细胞具有趋化作用。即使C8和C9大量过量存在，这种活性也没有受到显著影响。然而，如果C[unk]56与C7的相互作用是在过量红细胞存在的情况下发生的，这些细胞会结合C[unk]567并转化为EC567；且未发现趋化因子。
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The chemotactic activity for neutrophil and eosinophil leucocytes of the trimolecular complex of the fifth, sixth and seventh components of human complement (C567) prepared in free solution by the 'reactive lysis' procedure.通过“反应性溶解”程序在游离溶液中制备的人补体第五、第六和第七成分（C567）的三分子复合物对嗜中性粒细胞和嗜酸性粒细胞的趋化活性。
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本文引用的文献
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A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin.豚鼠血清与内毒素相互作用时从C'5衍生的一种嗜中性粒细胞趋化因子。
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Macrophage and neutrophil specific chemotactic factors in serum.血清中的巨噬细胞和中性粒细胞特异性趋化因子。
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Immunology. 1966 Aug;11(2):141-53.
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