哺乳动物磷脂的周转。培养的人淋巴细胞以及健康、饥饿和维生素A缺乏大鼠组织中的周转率和代谢异质性。
Turnover of mammalian phospholipids. Rates of turnover and metabolic heterogeneity in cultured human lymphocytes and in tissues of healthy, starved and vitamin A-deficient rats.
作者信息
Pasternak C A, Friedrichs B
出版信息
Biochem J. 1970 Sep;119(3):481-8. doi: 10.1042/bj1190481.
Abstract
- Choline- and inositol-labelled phospholipids of human cultured lymphocytes turn over in a biphasic manner; phytohaemagglutinin activation stimulates turnover. 2. Choline-labelled phospholipids of rat liver and kidney, but not of blood, turn over in vivo as fast as those of duodenum, ileum or colon. Turnover in the intestinal tissues is greater in fed than in starved or vitamin A-deficient rats. In each case phosphatidylcholine turns over relatively faster than sphingomyelin or lyso-phosphatidylcholine. 3. It is concluded that phospholipid turnover of the type described is a common feature of viable cells, and that metabolically favourable conditions increase, rather than decrease, turnover.
摘要
- 人培养淋巴细胞中胆碱和肌醇标记的磷脂以双相方式周转；植物血凝素激活可刺激周转。2. 大鼠肝脏和肾脏中胆碱标记的磷脂在体内的周转速度与十二指肠、回肠或结肠中的一样快，但血液中的则不然。喂食大鼠的肠道组织中的周转速度比饥饿或维生素A缺乏的大鼠更快。在每种情况下，磷脂酰胆碱的周转相对比鞘磷脂或溶血磷脂酰胆碱更快。3. 得出的结论是，所述类型的磷脂周转是活细胞的共同特征，并且代谢有利条件会增加而非减少周转。
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