Huis in 't Veld J H, van Palenstein Helderman W H, Dirks O B
Antonie Van Leeuwenhoek. 1979;45(1):25-33. doi: 10.1007/BF00400775.
Plaque samples from caries-active subjects showed a higher incidence of S. mutans than plaque samples from caries-free subjects. This was especially evident in approximal incisor plaque. S. mutans serotype d was almost exclusively present in approximal plaque obtained from caries-active subjects. Tooth surfaces infected with S. mutans still harbored this micro-organism 10 months later, while uninfected tooth surfaces remained free of S. mutans. Caries development predominantly occurs on those tooth surfaces which harbor relatively high percentages of S. mutans (> 5%). It is unlikely that serum or saliva antibodies against S. mutans play a major role in the protection against dental caries in these caries-free subjects since subjects with the greatest number of decayed surfaces showed the highest antibody titre as measured by haemagglutination or by the enzyme-linked immuno sorbent assay (ELISA).
患龋活跃受试者的菌斑样本中变形链球菌的发生率高于无龋受试者的菌斑样本。这在邻面切牙菌斑中尤为明显。变形链球菌d血清型几乎仅存在于患龋活跃受试者的邻面菌斑中。感染变形链球菌的牙面在10个月后仍有这种微生物存在，而未感染的牙面则没有变形链球菌。龋齿主要发生在那些变形链球菌比例相对较高（>5%）的牙面上。血清或唾液中针对变形链球菌的抗体在这些无龋受试者预防龋齿方面不太可能起主要作用，因为通过血凝试验或酶联免疫吸附测定（ELISA）测量，龋面最多的受试者抗体滴度最高。
