Nei J, Matsuda Y, Takada A
Dig Dis Sci. 1983 Mar;28(3):207-15. doi: 10.1007/BF01295115.
Fifteen heavy drinkers with the histological features of chronic hepatitis were studied. Chronic hepatitis observed in heavy drinkers can be divided into two categories. One is caused by alcohol, and the other is not etiologically related to alcohol. Chronic hepatitis caused by alcohol showed a definite improvement of clinical features following abstinence, as well as significantly high serum GOT/GPT ratios and high glutamate dehydrogenase activities on admission. These clinical features are distinctly different from chronic hepatitis without etiological relation to alcohol and resemble the other types of alcoholic liver injury. The leukocyte migration inhibition test by ethanol was more frequently positive in chronic hepatitis induced by alcohol than in the other types of alcoholic liver injury except for alcoholic hepatitis. Histological characteristics of the liver in chronic hepatitis induced by alcohol included the coexistence of features of both chronic hepatitis and alcoholic fibrosis. Three of four cases of chronic hepatitis induced by alcohol developed cirrhosis during the follow-up period. These results suggest that chronic hepatitis induced by alcohol is a type of alcoholic liver disease with an immunopathological etiology. It is a step toward the development of liver cirrhosis.
对15名具有慢性肝炎组织学特征的重度饮酒者进行了研究。重度饮酒者中观察到的慢性肝炎可分为两类。一类由酒精引起，另一类与酒精无病因学关联。酒精性慢性肝炎在戒酒后临床特征有明显改善，入院时血清谷草转氨酶/谷丙转氨酶比值显著升高，谷氨酸脱氢酶活性也较高。这些临床特征与与酒精无病因学关联的慢性肝炎明显不同，类似于其他类型的酒精性肝损伤。除酒精性肝炎外，酒精诱导的白细胞迁移抑制试验在酒精性慢性肝炎中比在其他类型的酒精性肝损伤中更常呈阳性。酒精性慢性肝炎的肝脏组织学特征包括慢性肝炎和酒精性纤维化特征并存。4例酒精性慢性肝炎患者中有3例在随访期间发展为肝硬化。这些结果表明，酒精性慢性肝炎是一种具有免疫病理学病因的酒精性肝病。它是肝硬化发展的一个阶段。
