Klein G, Svedmyr E, Jondal M, Persson P O
Int J Cancer. 1976 Jan 15;17(1):21-6. doi: 10.1002/ijc.2910170105.
After removal of SRBC rosette-forming T-cells from the peripheral blood, the residual, largely B-lymphocyte fraction of five infectious mononucleosis patients was found to contain 0.5-2% blast cells, positive for the EBV-determined nuclear antigen (EBNA). There was a rough parallelism between the presence of large lymphoblasts in the hematological smear, EBNS-positive large blasts in the B-cell fraction and the ability of the T-cell fraction to exert an EBV-specific lymphocytotoxicity on established cell lines in vitro. EBNA-positive B-cells and EBV-specific killer T-cells disappeared after the acute phase of the disease.
从外周血中去除形成SRBC玫瑰花结的T细胞后，发现5例传染性单核细胞增多症患者残留的主要为B淋巴细胞部分含有0.5% - 2%的母细胞，这些母细胞对EB病毒决定的核抗原（EBNA）呈阳性反应。血液涂片上大淋巴细胞的存在、B细胞部分中EBNA阳性的大母细胞以及T细胞部分在体外对已建立的细胞系发挥EB病毒特异性淋巴细胞毒性的能力之间存在大致的平行关系。疾病急性期过后，EBNA阳性B细胞和EB病毒特异性杀伤性T细胞消失。
