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双层脂质膜(BLM)对抗抗原-抗体相互作用的研究。

Bilayer lipid membranes (BLM) study of antigen-antibody interactions.

作者信息

Mountz J D, Tien H T

出版信息

J Bioenerg Biomembr. 1978 Dec;10(5-6):139-51. doi: 10.1007/BF00743104.

DOI:10.1007/BF00743104
PMID:555462
Abstract

Previous work of del Castillo and co-workers has shown that bilayer lipid membranes (BLM) can be used as transducers for detection of antigen-antibody reactions. The present experiments extend the previous work by incorporating complement into the BLM system. The results indicate that the antigen-antibody complex or the complement has no ability to affect the BLM system separately, but when carefully combined they will destabilize the BLM as a tool for investigating immunological reactions is suggested.

摘要

德尔卡斯蒂略及其同事之前的研究表明,双层脂质膜(BLM)可作为检测抗原-抗体反应的换能器。本实验通过将补体纳入BLM系统扩展了之前的研究。结果表明,抗原-抗体复合物或补体单独无法影响BLM系统,但当它们小心组合时,会使BLM不稳定,这表明其可作为研究免疫反应的工具。

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本文引用的文献

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Lipid films as transducers for detection of antigen-antibody and enzyme-substrate reactions.脂质膜作为用于检测抗原-抗体和酶-底物反应的传感器。
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Liposomes containing antiviral antibody can protect cells from virus infection.含有抗病毒抗体的脂质体可以保护细胞免受病毒感染。
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Biochemistry. 1976 Jan 27;15(2):452-60. doi: 10.1021/bi00647a034.
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Step conductance increases in bilayer membranes induced by antibody-antigen-complement action.抗体 - 抗原 - 补体作用诱导双层膜中的阶梯式电导增加。
Biochim Biophys Acta. 1975 Dec 1;413(2):317-21. doi: 10.1016/0005-2736(75)90117-0.
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Lectin-receptor interactions in liposomes.
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Serological reactions against glycolipid-sensitised liposomes in multiple sclerosis.多发性硬化症中针对糖脂致敏脂质体的血清学反应。
Nature. 1976;264(5588):785-7. doi: 10.1038/264785a0.