Fuller N J, Bates C J, Evans P H, Lucas A
Medical Research Council, Dunn Nutrition Unit, Cambridge, United Kingdom.
Eur J Pediatr. 1992 Jan;151(1):51-3. doi: 10.1007/BF02073892.
The former practice of giving 1 mg (2.27 mumoles) oral folic acid daily to premature infants receiving enteral feeds was assessed with respect to zinc status in Cambridge, United Kingdom. A group of 60 preterm infants, 80% of whom were receiving 1 mg oral folic acid daily, were studied for up to the first 16 weeks of life. Plasma folate and plasma zinc were measured for each subject. A significant inverse relationship was found between the maximum attained serum folate level and the minimum attained serum zinc level, (t = 5.0, 58 df, P less than 0.0001). This remained significant after corrections had been made for gestational age at birth, fetal growth retardation, birth weight, sex, diet, assisted ventilation and length of time to full enteral feeding. The hypothesis that very high folate intakes may adversely affect serum zinc levels and, by inference, zinc status in preterm infants could not be rejected. Caution is therefore advised when prescribing such very high folate doses daily for small preterm infants.
在英国剑桥，针对接受肠内喂养的早产儿每日口服1毫克（2.27微摩尔）叶酸的既往做法对锌状态的影响进行了评估。对一组60名早产儿进行了研究，其中80%的婴儿每日接受1毫克口服叶酸，研究持续至其出生后的前16周。对每个受试者测量了血浆叶酸和血浆锌。发现血清叶酸达到的最高水平与血清锌达到的最低水平之间存在显著的负相关关系（t = 5.0，自由度为58，P < 0.0001）。在对出生时的胎龄、胎儿生长迟缓、出生体重、性别、饮食、辅助通气以及完全肠内喂养所需时间进行校正后，这种相关性仍然显著。极高叶酸摄入量可能会对早产儿的血清锌水平产生不利影响，并由此推断对锌状态产生不利影响的这一假设不能被否定。因此，对于小早产儿每日开具如此高剂量的叶酸时建议谨慎。
