Thompson J A, Glasgow L A, Bray P F
Neurology. 1977 Mar;27(3):227-9. doi: 10.1212/wnl.27.3.227.
A serum/cerebrospinal fluid (CSF) ratio method was used to determine whether elevated CSF vaccinia antibody titers in some patients with multiple sclerosis are the result of central nervous system antibody synthesis or of a leak in the blood-brain barrier. Nine of 20 multiple sclerosis patients were noted to have a depressed serum/CSF vaccinia antibody ratio and a normal ratio for poliovirus-I, an agent thought not to be involved in the pathogenesis of multiple sclerosis. These data suggest central nervous system synthesis of vaccinia neutralizing antibody. Vaccinia virus antigens may play an important direct or indirect role in the pathogenesis of multiple sclerosis.
采用血清/脑脊液（CSF）比值法来确定某些多发性硬化症患者脑脊液中牛痘抗体滴度升高是中枢神经系统抗体合成的结果，还是血脑屏障渗漏所致。在20例多发性硬化症患者中，有9例的血清/脑脊液牛痘抗体比值降低，而脊髓灰质炎病毒I的比值正常，脊髓灰质炎病毒I被认为与多发性硬化症的发病机制无关。这些数据提示中枢神经系统合成牛痘中和抗体。牛痘病毒抗原可能在多发性硬化症的发病机制中发挥重要的直接或间接作用。
