Weiner H L, Cherry J, McIntosh K
Neurology. 1978 May;28(5):415-20. doi: 10.1212/wnl.28.5.415.
Lymphocyte transformation to vaccinia virus was measured in multiple sclerosis (MS) patients and normal controls. There was a significant reduction of lymphocyte transformation to vaccinia virus in multiple sclerosis patients compared with the control group. In addition, a positive correlation existed between the degree of disability of the multiple sclerosis patients and the extent of lymphocyte transformation in the presence of vaccinia virus. There was no correlation between cell-mediated immunity to vaccinia virus and either serum or cerebrospinal fluid (CSF) antibody levels to vaccinia in multiple sclerosis patients or controls, all of whom had been previously vaccinated. In conjunction with other studies, all of whom had been previously vaccinated. In conjunction with other studies that have demonstrated elevated antibody titers to vaccinia virus in the CSF of multiple sclerosis patients, these results support the possibility that vaccinia virus may play a role in the pathogenesis of multiple sclerosis.
在多发性硬化症（MS）患者和正常对照中检测了淋巴细胞对痘苗病毒的转化情况。与对照组相比，多发性硬化症患者淋巴细胞对痘苗病毒的转化显著降低。此外，在存在痘苗病毒的情况下，多发性硬化症患者的残疾程度与淋巴细胞转化程度之间存在正相关。在多发性硬化症患者或对照中，对痘苗病毒的细胞介导免疫与血清或脑脊液（CSF）中针对痘苗的抗体水平均无相关性，所有这些患者此前均已接种过疫苗。结合其他研究，所有这些患者此前均已接种过疫苗。结合其他已证明多发性硬化症患者脑脊液中痘苗病毒抗体滴度升高的研究，这些结果支持痘苗病毒可能在多发性硬化症发病机制中起作用的可能性。
