Soll A H
J Gen Physiol. 1967 Dec;50(11):2565-78. doi: 10.1085/jgp.50.11.2565.
A cylindrical treatment of the configuration of small molecules in solution has been proposed. Cylindrical dimensions were obtained from Fisher-Hirschfelder molecular models, and these dimensions were used in an analysis of three sets of reflection coefficient values from the literature. The correlation between solute dimensions and the reflection coefficient was subjected to both statistical analyses and graphical examination, with particular emphasis given to parameter interdependence. The results consistently indicated a significant relation between the reflection coefficient and solute diameter. The dependence on diameter suggests a lengthwise orientation of solute within the membrane. Furthermore it is shown that this orientation is occurring within the aqueous region of the membrane, and thus this region has a structural characteristic which is responsible for the lengthwise orientation of solute.
有人提出了一种关于溶液中小分子构型的柱状处理方法。柱状尺寸是从费舍尔 - 赫希费尔德分子模型中获得的，这些尺寸被用于分析文献中的三组反射系数值。溶质尺寸与反射系数之间的相关性经过了统计分析和图形检验，特别强调了参数的相互依赖性。结果一致表明反射系数与溶质直径之间存在显著关系。对直径的依赖性表明溶质在膜内呈纵向取向。此外，研究表明这种取向发生在膜的水相区域内，因此该区域具有一种结构特征，这种结构特征导致了溶质的纵向取向。
