脱氧核糖核酸哺乳动物病毒的病毒致癌机制。IV. 由“高”致癌性12型、18型和31型腺病毒诱导的肿瘤细胞中相关病毒特异性核糖核酸
Mechanism of viral carcinogenesis by deoxyribonucleic acid mammalian viruses. IV. Related virus-specific ribonucleic acids in tumor cells induced by "highly" oncogenic adenovirus types 12, 18, and 31.
作者信息
Fujinaga K, Green M
出版信息
J Virol. 1967 Jun;1(3):576-82. doi: 10.1128/JVI.1.3.576-582.1967.
Abstract
Formation of hybrids between viral deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) was used to detect virus-specific RNA in the nuclei and polyribosomes of transformed and tumor cells induced by "highly" oncogenic human adenovirus (Ad) types 12, 18, and 31. The presence of virus-specific RNA in the cell nucleus, and the inhibitory effect of actinomycin D on its synthesis, suggest that adenovirus-specific RNA is transcribed from a DNA template in the nucleus. Ad 12, 18, and 31 virus-specific RNA did not hybridize significantly with the DNA of the "weakly" oncogenic adenovirus group (Ad 3, 7, 11, 14, 16, and 21) or with that of nononcogenic Ad 2 and 4. Labeled RNA from Ad 12, 18, and 31 tumor cells hybridized with heterologous Ad 12, 18, and 31 DNA 30 to 60% as efficiently as with homologous DNA. Thus, common viral genes are transcribed in tumor cells induced by Ad 12, 18, and 31.
摘要
利用病毒脱氧核糖核酸（DNA）与核糖核酸（RNA）形成杂交体的方法，来检测由“高”致癌性人腺病毒12型、18型和31型诱导的转化细胞和肿瘤细胞核及多核糖体中的病毒特异性RNA。细胞核中存在病毒特异性RNA，以及放线菌素D对其合成的抑制作用，表明腺病毒特异性RNA是从细胞核中的DNA模板转录而来。腺病毒12型、18型和31型的病毒特异性RNA与“低”致癌性腺病毒组（腺病毒3型、7型、11型、14型、16型和21型）的DNA或非致癌性腺病毒2型和4型的DNA均未发生明显杂交。来自腺病毒12型、18型和31型肿瘤细胞的标记RNA与异源腺病毒12型、18型和31型DNA杂交的效率，为与同源DNA杂交效率的30%至60%。因此，腺病毒12型、18型和31型诱导的肿瘤细胞中会转录共同的病毒基因。
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