脱氧核糖核酸哺乳动物病毒的病毒致癌机制。IV. 由“高”致癌性12型、18型和31型腺病毒诱导的肿瘤细胞中相关病毒特异性核糖核酸
Mechanism of viral carcinogenesis by deoxyribonucleic acid mammalian viruses. IV. Related virus-specific ribonucleic acids in tumor cells induced by "highly" oncogenic adenovirus types 12, 18, and 31.
作者信息
Fujinaga K, Green M
出版信息
J Virol. 1967 Jun;1(3):576-82. doi: 10.1128/JVI.1.3.576-582.1967.
Abstract
Formation of hybrids between viral deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) was used to detect virus-specific RNA in the nuclei and polyribosomes of transformed and tumor cells induced by "highly" oncogenic human adenovirus (Ad) types 12, 18, and 31. The presence of virus-specific RNA in the cell nucleus, and the inhibitory effect of actinomycin D on its synthesis, suggest that adenovirus-specific RNA is transcribed from a DNA template in the nucleus. Ad 12, 18, and 31 virus-specific RNA did not hybridize significantly with the DNA of the "weakly" oncogenic adenovirus group (Ad 3, 7, 11, 14, 16, and 21) or with that of nononcogenic Ad 2 and 4. Labeled RNA from Ad 12, 18, and 31 tumor cells hybridized with heterologous Ad 12, 18, and 31 DNA 30 to 60% as efficiently as with homologous DNA. Thus, common viral genes are transcribed in tumor cells induced by Ad 12, 18, and 31.
摘要
利用病毒脱氧核糖核酸（DNA）与核糖核酸（RNA）形成杂交体的方法，来检测由“高”致癌性人腺病毒12型、18型和31型诱导的转化细胞和肿瘤细胞核及多核糖体中的病毒特异性RNA。细胞核中存在病毒特异性RNA，以及放线菌素D对其合成的抑制作用，表明腺病毒特异性RNA是从细胞核中的DNA模板转录而来。腺病毒12型、18型和31型的病毒特异性RNA与“低”致癌性腺病毒组（腺病毒3型、7型、11型、14型、16型和21型）的DNA或非致癌性腺病毒2型和4型的DNA均未发生明显杂交。来自腺病毒12型、18型和31型肿瘤细胞的标记RNA与异源腺病毒12型、18型和31型DNA杂交的效率，为与同源DNA杂交效率的30%至60%。因此，腺病毒12型、18型和31型诱导的肿瘤细胞中会转录共同的病毒基因。
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本文引用的文献
1
Antigenic Variation Among Adenovirus Type 12 Strains.
J Bacteriol. 1965 Jul;90(1):292-3. doi: 10.1128/jb.90.1.292-293.1965.
2
HUMAN ADENOVIRUS TYPE 31. A NEW SEROTYPE WITH ONCOGENIC PROPERTIES.
Lancet. 1965 Jan 2;1(7375):21-3. doi: 10.1016/s0140-6736(65)90925-6.
3
BIOCHEMICAL STUDIES ON ADENOVIRUS MULTIPLICATION. VII. HOMOLOGY BETWEEN DNA'S OF TUMORIGENIC AND NONTUMORIGENIC HUMAN ADENOVIRUSES.
Proc Natl Acad Sci U S A. 1964 Oct;52(4):1053-9. doi: 10.1073/pnas.52.4.1053.
4
BIOCHEMICAL STUDIES ON ADENOVIRUS MULTIPLICATION, VI. PROPERTIES OF HIGHLY PURIFIED TUMORIGENIC HUMAN ADENOVIRUSES AND THEIR DNA.
Proc Natl Acad Sci U S A. 1964 Jun;51(6):1251-9. doi: 10.1073/pnas.51.6.1251.
5
TESTS IN HAMSTERS FOR ONCOGENIC QUALITY OF ORDINARY VIRUSES INCLUDING ADENOVIRUS TYPE 7.
Proc Soc Exp Biol Med. 1964 Apr;115:1141-50. doi: 10.3181/00379727-115-29138.
6
Oncogenic effects in hamsters of human adenovirus types 12 and 18.
Proc Natl Acad Sci U S A. 1962 Dec 15;48(12):2051-8. doi: 10.1073/pnas.48.12.2051.
7
Biochemical studies on adenovirus multiplication. IV. Isolation, purification, and chemical analysis of adenovirus.
Virology. 1963 May;20:199-207. doi: 10.1016/0042-6822(63)90157-0.
8
The quest for human cancer viruses.
Science. 1962 Sep 14;137(3533):835-41. doi: 10.1126/science.137.3533.835.
9
The mechanism of viral carcinogenesis by DNA mammalian viruses: viral-specific RNA in polyribosomes of adenovirus tumor and transformed cells.
Proc Natl Acad Sci U S A. 1966 Jun;55(6):1567-74. doi: 10.1073/pnas.55.6.1567.
10
Biochemical studies on adenovirus multiplication. IX. Chemical and base composition analysis of 28 human adenoviruses.
Proc Natl Acad Sci U S A. 1965 Aug;54(2):547-51. doi: 10.1073/pnas.54.2.547.
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