• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Mechanism of viral carcinogenesis by deoxyribonucleic acid mammalian viruses. IV. Related virus-specific ribonucleic acids in tumor cells induced by "highly" oncogenic adenovirus types 12, 18, and 31.脱氧核糖核酸哺乳动物病毒的病毒致癌机制。IV. 由“高”致癌性12型、18型和31型腺病毒诱导的肿瘤细胞中相关病毒特异性核糖核酸
J Virol. 1967 Jun;1(3):576-82. doi: 10.1128/JVI.1.3.576-582.1967.
2
Mechanism of viral carcinogenesis by DNA mammalian viruses. VII. Viral genes transcribed in adenovirus type 2 infected and transformed cells.DNA 哺乳动物病毒的病毒致癌机制。VII. 在 2 型腺病毒感染和转化细胞中转录的病毒基因。
Proc Natl Acad Sci U S A. 1970 Feb;65(2):375-82. doi: 10.1073/pnas.65.2.375.
3
Mechanism of viral carcinogenesis by DNA mammalian viruses. V. Properties of purified viral-specific RNA from human adenovirus-induced tumor cells.DNA 哺乳动物病毒引发病毒致癌的机制。V. 来自人腺病毒诱导肿瘤细胞的纯化病毒特异性RNA的特性
J Mol Biol. 1968 Jan 14;31(1):63-73. doi: 10.1016/0022-2836(68)90054-5.
4
The mechanism of viral carcinogenesis by DNA mammalian viruses. VI. A new class of virus-specific RNA molecules in cells transformed by group C human adenoviruses.DNA哺乳动物病毒的病毒致癌机制。VI. C组人腺病毒转化细胞中一类新的病毒特异性RNA分子。
Proc Natl Acad Sci U S A. 1969 Sep;64(1):255-62. doi: 10.1073/pnas.64.1.255.
5
Effect of oncogenic DNA viruses on regulatory mechanisms of cells.
Fed Proc. 1970 May-Jun;29(3):1265-75.
6
The mechanism of viral carcinogenesis by DNA mammalian viruses: RNA transcripts containing viral and highly reiterated cellular base sequences in adenovirus-transformed cells (DNA-RNA hybridization-viral-cell mRNA).DNA哺乳动物病毒的病毒致癌机制：腺病毒转化细胞中含有病毒和高度重复细胞碱基序列的RNA转录本（DNA-RNA杂交-病毒-细胞mRNA）
Proc Natl Acad Sci U S A. 1972 Feb;69(2):427-30. doi: 10.1073/pnas.69.2.427.
7
Characteristics of the syrian hamster ribonucleic acid present in cells transformed by polyoma, simian virus 40, or adenovirus 12.多瘤病毒、猴病毒40或腺病毒12转化细胞中存在的叙利亚仓鼠核糖核酸的特征。
J Virol. 1969 Feb;3(2):119-25. doi: 10.1128/JVI.3.2.119-125.1969.
8
Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. II. Relationship of adenovirus 2 deoxyribonucleic acid and simian virus 40 deoxyribonucleic acid in the Ad2+ND genome.无缺陷腺病毒2-猴病毒40杂交病毒的研究。II. 腺病毒2脱氧核糖核酸与猴病毒40脱氧核糖核酸在Ad2+ND基因组中的关系。
J Virol. 1971 Mar;7(3):343-51. doi: 10.1128/JVI.7.3.343-351.1971.
9
Biochemical studies on adenovirus multiplication. 13. Synthesis of virus-specific ribonucleic acid during infection with human adenovirus type 12.腺病毒增殖的生化研究。13. 人12型腺病毒感染期间病毒特异性核糖核酸的合成
J Virol. 1968 Oct;2(10):1055-63. doi: 10.1128/JVI.2.10.1055-1063.1968.
10
In vitro transformation by the adenovirus-simian virus 40 hybrid viruses. V. Virus-specific ribonucleic acid in cell lines transformed by the adenovirus 2-simian virus 40 and adenovirus 12-simian virus 40 transcapsidant hybrid viruses.腺病毒-猴病毒40杂交病毒的体外转化。V. 由腺病毒2-猴病毒40和腺病毒12-猴病毒40转壳杂交病毒转化的细胞系中的病毒特异性核糖核酸。
J Virol. 1969 Nov;4(5):704-11. doi: 10.1128/JVI.4.5.704-711.1969.

引用本文的文献

1
Adenovirus type 12-induced rat tumor cells of neuroepithelial origin: persistence and expression of the viral genome.12型腺病毒诱导的神经上皮起源大鼠肿瘤细胞：病毒基因组的持久性和表达
J Virol. 1980 Jan;33(1):423-37. doi: 10.1128/JVI.33.1.423-437.1980.
2
Biochemical studies on adenovirus multiplication. 13. Synthesis of virus-specific ribonucleic acid during infection with human adenovirus type 12.腺病毒增殖的生化研究。13. 人12型腺病毒感染期间病毒特异性核糖核酸的合成
J Virol. 1968 Oct;2(10):1055-63. doi: 10.1128/JVI.2.10.1055-1063.1968.
3
Mechanism of viral carcinogenesis by DNA mammalian viruses. VII. Viral genes transcribed in adenovirus type 2 infected and transformed cells.DNA 哺乳动物病毒的病毒致癌机制。VII. 在 2 型腺病毒感染和转化细胞中转录的病毒基因。
Proc Natl Acad Sci U S A. 1970 Feb;65(2):375-82. doi: 10.1073/pnas.65.2.375.
4
The mechanism of viral carcinogenesis by DNA mammalian viruses. VI. A new class of virus-specific RNA molecules in cells transformed by group C human adenoviruses.DNA哺乳动物病毒的病毒致癌机制。VI. C组人腺病毒转化细胞中一类新的病毒特异性RNA分子。
Proc Natl Acad Sci U S A. 1969 Sep;64(1):255-62. doi: 10.1073/pnas.64.1.255.
5
Transformation of primary rat embryo cells by adenovirus type 2.2型腺病毒对原代大鼠胚胎细胞的转化
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1205-12. doi: 10.1073/pnas.58.3.1205.
6
Virus-specific ribonucleic acid in the nucleus and cytoplasm of rat embryo cells transformed by adenovirus type 2.由2型腺病毒转化的大鼠胚胎细胞核与细胞质中的病毒特异性核糖核酸
J Virol. 1972 Oct;10(4):648-52. doi: 10.1128/JVI.10.4.648-652.1972.
7
Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma.小鼠乳腺癌细胞中病毒特异性RNA翻译的证据。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):535-8. doi: 10.1073/pnas.69.3.535.
8
SV40-specific RNA in the nucleus and polyribosomes of transformed cells.转化细胞的细胞核和多核糖体中的SV40特异性RNA。
Proc Natl Acad Sci U S A. 1970 Apr;65(4):1089-96. doi: 10.1073/pnas.65.4.1089.
9
In vitro transformation by the adenovirus-simian virus 40 hybrid viruses. V. Virus-specific ribonucleic acid in cell lines transformed by the adenovirus 2-simian virus 40 and adenovirus 12-simian virus 40 transcapsidant hybrid viruses.腺病毒-猴病毒40杂交病毒的体外转化。V. 由腺病毒2-猴病毒40和腺病毒12-猴病毒40转壳杂交病毒转化的细胞系中的病毒特异性核糖核酸。
J Virol. 1969 Nov;4(5):704-11. doi: 10.1128/JVI.4.5.704-711.1969.
10
Human cell strains susceptible to focus formation by human adenovirus type 12.对12型人腺病毒形成蚀斑敏感的人细胞株。
Proc Natl Acad Sci U S A. 1968 Dec;61(4):1272-8. doi: 10.1073/pnas.61.4.1272.

本文引用的文献

1
Antigenic Variation Among Adenovirus Type 12 Strains.12型腺病毒株之间的抗原变异
J Bacteriol. 1965 Jul;90(1):292-3. doi: 10.1128/jb.90.1.292-293.1965.
2
HUMAN ADENOVIRUS TYPE 31. A NEW SEROTYPE WITH ONCOGENIC PROPERTIES.人31型腺病毒。一种具有致癌特性的新型血清型。
Lancet. 1965 Jan 2;1(7375):21-3. doi: 10.1016/s0140-6736(65)90925-6.
3
BIOCHEMICAL STUDIES ON ADENOVIRUS MULTIPLICATION. VII. HOMOLOGY BETWEEN DNA'S OF TUMORIGENIC AND NONTUMORIGENIC HUMAN ADENOVIRUSES.腺病毒增殖的生化研究。VII. 致瘤性和非致瘤性人腺病毒DNA之间的同源性。
Proc Natl Acad Sci U S A. 1964 Oct;52(4):1053-9. doi: 10.1073/pnas.52.4.1053.
4
BIOCHEMICAL STUDIES ON ADENOVIRUS MULTIPLICATION, VI. PROPERTIES OF HIGHLY PURIFIED TUMORIGENIC HUMAN ADENOVIRUSES AND THEIR DNA.腺病毒增殖的生化研究，VI. 高度纯化的致瘤人类腺病毒及其DNA的特性
Proc Natl Acad Sci U S A. 1964 Jun;51(6):1251-9. doi: 10.1073/pnas.51.6.1251.
5
TESTS IN HAMSTERS FOR ONCOGENIC QUALITY OF ORDINARY VIRUSES INCLUDING ADENOVIRUS TYPE 7.用仓鼠对包括7型腺病毒在内的普通病毒的致癌性进行检测。
Proc Soc Exp Biol Med. 1964 Apr;115:1141-50. doi: 10.3181/00379727-115-29138.
6
Oncogenic effects in hamsters of human adenovirus types 12 and 18.人类腺病毒12型和18型对仓鼠的致癌作用。
Proc Natl Acad Sci U S A. 1962 Dec 15;48(12):2051-8. doi: 10.1073/pnas.48.12.2051.
7
Biochemical studies on adenovirus multiplication. IV. Isolation, purification, and chemical analysis of adenovirus.腺病毒增殖的生化研究。IV. 腺病毒的分离、纯化及化学分析。
Virology. 1963 May;20:199-207. doi: 10.1016/0042-6822(63)90157-0.
8
The quest for human cancer viruses.对人类癌症病毒的探索。
Science. 1962 Sep 14;137(3533):835-41. doi: 10.1126/science.137.3533.835.
9
The mechanism of viral carcinogenesis by DNA mammalian viruses: viral-specific RNA in polyribosomes of adenovirus tumor and transformed cells.DNA哺乳动物病毒的病毒致癌机制：腺病毒肿瘤和转化细胞多核糖体中的病毒特异性RNA
Proc Natl Acad Sci U S A. 1966 Jun;55(6):1567-74. doi: 10.1073/pnas.55.6.1567.
10
Biochemical studies on adenovirus multiplication. IX. Chemical and base composition analysis of 28 human adenoviruses.腺病毒增殖的生化研究。IX. 28种人类腺病毒的化学和碱基组成分析。
Proc Natl Acad Sci U S A. 1965 Aug;54(2):547-51. doi: 10.1073/pnas.54.2.547.

脱氧核糖核酸哺乳动物病毒的病毒致癌机制。IV. 由“高”致癌性12型、18型和31型腺病毒诱导的肿瘤细胞中相关病毒特异性核糖核酸

Mechanism of viral carcinogenesis by deoxyribonucleic acid mammalian viruses. IV. Related virus-specific ribonucleic acids in tumor cells induced by "highly" oncogenic adenovirus types 12, 18, and 31.

作者信息

Fujinaga K, Green M

出版信息

J Virol. 1967 Jun;1(3):576-82. doi: 10.1128/JVI.1.3.576-582.1967.

DOI:10.1128/JVI.1.3.576-582.1967
PMID:5630384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375283/
Abstract

Formation of hybrids between viral deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) was used to detect virus-specific RNA in the nuclei and polyribosomes of transformed and tumor cells induced by "highly" oncogenic human adenovirus (Ad) types 12, 18, and 31. The presence of virus-specific RNA in the cell nucleus, and the inhibitory effect of actinomycin D on its synthesis, suggest that adenovirus-specific RNA is transcribed from a DNA template in the nucleus. Ad 12, 18, and 31 virus-specific RNA did not hybridize significantly with the DNA of the "weakly" oncogenic adenovirus group (Ad 3, 7, 11, 14, 16, and 21) or with that of nononcogenic Ad 2 and 4. Labeled RNA from Ad 12, 18, and 31 tumor cells hybridized with heterologous Ad 12, 18, and 31 DNA 30 to 60% as efficiently as with homologous DNA. Thus, common viral genes are transcribed in tumor cells induced by Ad 12, 18, and 31.

摘要

利用病毒脱氧核糖核酸（DNA）与核糖核酸（RNA）形成杂交体的方法，来检测由“高”致癌性人腺病毒12型、18型和31型诱导的转化细胞和肿瘤细胞核及多核糖体中的病毒特异性RNA。细胞核中存在病毒特异性RNA，以及放线菌素D对其合成的抑制作用，表明腺病毒特异性RNA是从细胞核中的DNA模板转录而来。腺病毒12型、18型和31型的病毒特异性RNA与“低”致癌性腺病毒组（腺病毒3型、7型、11型、14型、16型和21型）的DNA或非致癌性腺病毒2型和4型的DNA均未发生明显杂交。来自腺病毒12型、18型和31型肿瘤细胞的标记RNA与异源腺病毒12型、18型和31型DNA杂交的效率，为与同源DNA杂交效率的30%至60%。因此，腺病毒12型、18型和31型诱导的肿瘤细胞中会转录共同的病毒基因。