Zakusov V V, Liubimov B I, Iavorskiĭ A N, Fokin V I
Biull Eksp Biol Med. 1977 Jun;83(6):693-6.
A selective uptake of ethanol by presenting its 5% solution as the only source of fluid was elaborated in rats for 2 months. It was found that lithium chloride injected intravenously in a dose of 35 mg/kg twice per 24 hours for 14 days depressed the ethanol preference causing a motivation inversion whose mechanism was associated with the changes in the activity of the hypothalamic centres of the neuroendocrine regulation. A possibility of lithium salts in the therapy of chronic alcoholism is discussed.
通过将5%的乙醇溶液作为唯一的液体来源，在大鼠中精心设计了2个月的乙醇选择性摄取实验。结果发现，每24小时静脉注射35毫克/千克剂量的氯化锂，持续14天，会降低大鼠对乙醇的偏好，导致动机反转，其机制与神经内分泌调节的下丘脑中心活动变化有关。文中讨论了锂盐治疗慢性酒精中毒的可能性。
