Iavorskiĭ A N, Liubimov B I
Biull Eksp Biol Med. 1978 Aug;86(8):194-7.
Ethanol, used for 2 months in a 5% solution, disorganized the circadian cycle of the hystophysiologic activity of the rat epiphysis. During prolonged (course) administration in the doses close to those used at the clinic lithium chloride normalized the mentioned changes and also prevented their development in case of joint two-months use of ethanol and lithium salt. This effect of the drug correlates with the inhibition or prevention of the ethanol preference development observed under these perimental conditions. A possible interrelationship between the discovered capacity of lithium salt to normalize the chronobiological derangements of the epiphysis and clinical efficacy of these salts in alcoholism and other affective periodical disorders is discussed.
在大鼠松果体的生理活动中，使用5%乙醇溶液持续两个月会打乱其昼夜节律。在接近临床使用剂量的情况下，长期（疗程）给予氯化锂可使上述变化恢复正常，并且在乙醇和锂盐联合使用两个月的情况下，还能防止这些变化的发生。该药物的这种作用与在这些实验条件下观察到的抑制或预防乙醇偏好形成有关。文中讨论了所发现的锂盐使松果体的时间生物学紊乱恢复正常的能力与这些盐在酒精中毒和其他情感周期性障碍中的临床疗效之间可能存在的相互关系。
