一种由小单孢菌属产生的新放线菌素复合物：发酵、分离及特性研究

A new actinomycin complex produced by a Micromonospora species: fermentation, isolation, and characterization.

作者信息

Wagman G H, Marquez J A, Watkins P D, Gentile F, Murawski A, Patel M, Weinstein M J

出版信息

Antimicrob Agents Chemother. 1976 Mar;9(3):465-9. doi: 10.1128/AAC.9.3.465.

DOI:10.1128/AAC.9.3.465

PMID:56917

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429553/

Abstract

A species of Micromonospora, Micromonospora floridensis NRRL 8020, has been found to produce an actinomycin complex consisting of at least 25 active components. After solvent extraction of the complex, separation of the individual components was carried out by preparative thin-layer chromatography. Hydrolysis and subsequent electrophoretic and chromatographic identification of the amino acid content of each of the isolated components have shown differences from known actinomycins, and the probability exists that these contain a number of amino or imino acids not previously found in other members of this group of antibiotics.

摘要

已发现一种小单孢菌，即佛罗里达小单孢菌NRRL 8020，能产生一种由至少25种活性成分组成的放线菌素复合物。该复合物经溶剂萃取后，通过制备型薄层色谱法分离各成分。对每种分离成分的氨基酸含量进行水解以及随后的电泳和色谱鉴定，结果表明其与已知放线菌素存在差异，而且这些成分有可能含有一些此前在这类抗生素的其他成员中未发现的氨基酸或亚氨基酸。

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