通过体细胞遗传学将乙二醛酶I基因定位到小鼠第17号染色体上。
Assignment of the gene for glyoxylase I to mouse chromosome 17 by somatic cell genetics.
作者信息
Leinwand L, Nichols E, Ruddle F H
出版信息
Biochem Genet. 1978 Aug;16(7-8):659-66. doi: 10.1007/BF00484722.
PMID:569476
Abstract
Evidence is presented for the assignment of the gene for glyoxylase I to mouse chromosome 17 using mouse X Chinese hamster somatic cell hybrids. GLO I was not expressed concordantly with any known marker enzymes which represented 11 linkage groups. The presence of chromosome 17 and expression of GLO I were concordant in 31/31 clones. GLO I is thus linked to the H-2 histocompatibility locus in the mouse.
摘要
利用小鼠与中国仓鼠体细胞杂种，提供了将乙二醛酶I基因定位于小鼠第17号染色体的证据。乙二醛酶I的表达与代表11个连锁群的任何已知标记酶不一致。在31个克隆中，第17号染色体的存在与乙二醛酶I的表达是一致的。因此，乙二醛酶I与小鼠的H-2组织相容性位点相连。
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